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Review
. 2022 Oct-Dec;29(4):335-346.
doi: 10.1016/j.rcreu.2022.05.003. Epub 2022 Aug 10.

[Guillain Barré syndrome in the paediatric population. Consequence of active infection or long Covid?]

[Article in Spanish]
Erika Barroso  1 , Eduardo Tuta-Quintero  1 , Juan Olivella  1 , Camila Aragón  1 , Lorena Vásquez  1 , Lina Acosta  1 , Oscar Pinzón  1 , Carlos A Pantoja  1 , Estefanía Collazos  1 , Yesica P Ascanio  1 , Violett Del Carmen Del Río Morales  1 , Juan C Kuan  1 , Liley A Velásquez  2 , Yeimy N Díaz  2 , Juan Pimentel  3
Affiliations
Review

[Guillain Barré syndrome in the paediatric population. Consequence of active infection or long Covid?]

[Article in Spanish]
Erika Barroso et al. Rev Colomb Reumatol. 2022 Oct-Dec.

Abstract
in English, Spanish

Background: Guillain-Barré syndrome is a polyradiculoneuropathy that has been associated with infectious diseases as triggers. There is currently little medical evidence exploring the relationship between the development of Guillain-Barré syndrome caused by SARS-CoV-2 infection and long Covid.

Objective: To synthesize the medical evidence that describes the relationship between post Covid syndrome and Guillain-Barré syndrome in the paediatric population.

Methodology: A scoping review was developed using Scopus and PubMed databases, including analytical and/or descriptive experimental and observational studies.

Results: The main clinical manifestations presented by paediatric patients were distal and ascending weakness in the lower limbs and myalgia. The diagnostic approach was based on clinical findings, imaging findings on spinal magnetic resonance and electromyography. The therapeutic strategy is based on the use of intravenous human immunoglobulins.

Conclusion: Guillain-Barré syndrome is a frequent disease in the paediatric population with active SARS-CoV-2 infection or in survivors, however, it is necessary to encourage further clinical studies that increase the medical literature that describes this association.

Introducción: El síndrome de Guillain-Barré es una polirradiculoneuropatía que se ha asociado con enfermedades infecciosas como desencadenantes. En la actualidad es escasa la evidencia médica que explore la relación entre el desarrollo del síndrome de Guillain-Barré causado por la infección por SARS-CoV-2 y la COVID prolongada.

Objetivo: Sintetizar la evidencia médica que describe la relación entre el síndrome pos-COVID y el síndrome de Guillain-Barré en la población pediátrica.

Metodología: Se realizó una revisión exploratoria utilizando las bases de datos de Scopus y PubMed, incluyendo estudios experimentales y observacionales analíticos o descriptivos.

Resultados: Las principales manifestaciones clínicas presentadas por los pacientes fueron debilidad distal y ascendente en miembros inferiores y mialgias. El enfoque diagnóstico se apoyó en los hallazgos clínicos, hallazgos imagenológicos por resonancia magnética de columna y electromiografía. La estrategia terapéutica se basó en el uso de inmunoglobulinas humanas intravenosas.

Conclusión: El síndrome de Guillain-Barré es una enfermedad frecuente en la población pediátrica con infección activa por SARS-CoV-2 o en sobrevivientes, sin embargo, es necesario incentivar el desarrollo de estudios clínicos que incrementen la literatura médica que describe esta asociación.

Keywords: COVID-19; Guillain-Barre syndrome; Post-acute COVID-19 syndrome; SARS-CoV-2.

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