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Review
. 2025 Jun 6;19(1):73.
doi: 10.1007/s12105-025-01807-w.

Etiopathogenesis of Oral Lichen Planus: A Review

Gabriel Bassan Marinho Maciel  1 , Taline Laura Guse  2 , Roberto Marinho Maciel  3 , Cristiane Cademartori Danesi  3
Affiliations
Review

Etiopathogenesis of Oral Lichen Planus: A Review

Gabriel Bassan Marinho Maciel et al. Head Neck Pathol. .

Abstract

Background: Oral lichen planus (OLP) is a chronic immune-mediated disease affecting the mucous membranes of the oral cavity, regarded as a potentially malignant disorder.

Methods: We performed a narrative review of the literature compiling key hypotheses on the etiopathogenesis of OLP, addressing recently raised aspects and questions yet to be elucidated.

Results: The etiopathogenesis of OLP is complex and not fully understood, with evidence suggesting a multifactorial cause. Lesions appear to be triggered by the recognition of one or more antigens, provoking a dysregulated T-cell-mediated immune response against oral keratinocytes. Genetic and environmental factors significantly influence the orchestration of various immune and non-immune cells, cytokines, and molecules involved in this pathological process.

Conclusions: Understanding recent theories on the etiopathogenesis of OLP is crucial forguiding future research on its diagnosis and treatment, as well as on preventing its malignant transformation.

Keywords: Apoptosis; Inflammation; Lichen planus, oral; Mouth neoplasms; Pyroptosis.

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Conflict of interest statement

Declarations. Ethics Approval and Consent to Participate: Not applicable. Competing Interests: The authors declare no competing interests.

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References

    1. Binnie R, Dobson ML, Chrystal A, Hijazi K (2024) Oral lichen planus and lichenoid lesions - challenges and pitfalls for the general dental practitioner. Br Dent J 236(4):285–292. 10.1038/s41415-024-7063-y - PMC - PubMed
    1. Chen X, Zhang S, Wu X, Lei Y, Lei B, Zhao Z (2024) Inflammatory cytokines and oral lichen planus: a Mendelian randomization study. Front Immunol Feb 7:15:1332317. 10.3389/fimmu.2024.1332317 - PMC - PubMed
    1. Lavoro A, Cultrera G, Gattuso G, Lombardo C, Falzone L, Saverio C, Libra M, Salmeri M (2024) Role of oral microbiota dysbiosis in the development and progression of oral lichen planus. J Pers Med 14(4):386. 10.3390/jpm14040386 - PMC - PubMed
    1. Villa TG, Sánchez-Pérez Á, Sieiro C (2021) Oral lichen planus: a microbiologist point of view. Int Microbiol 24(3):275–289. 10.1007/s10123-021-00168-y - PMC - PubMed
    1. Vičić M, Hlača N, Kaštelan M, Brajac I, Sotošek V, Prpić Massari L (2023) Comprehensive insight into lichen planus Immunopathogenesis. Int J Mol Sci 24(3):3038. 10.3390/ijms24033038 - PMC - PubMed

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