Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov 16.
doi: 10.1016/j.rcreu.2022.10.003. Online ahead of print.

[SARS-CoV-2 and post-COVID-19 syndrome in paediatric rheumatology: A scoping review]

[Article in Spanish]
Eduardo Tuta Quintero  1 , Angela C Mosquera Pongutá  2 , Erika Alexandra Barroso da Silva  1 , Juan Olivella  1 , Andrea Alexandra Silvera  3 , Camila Aragón  1 , Lorena Vásquez  1 , Estefanía Collazos  1 , Karla Olivares Vigles  3 , Karol Martínez  1 , Mateo León Machicado  4 , Yeimy N Díaz Pérez  5 , Juan Pimentel  1
Affiliations
Review

[SARS-CoV-2 and post-COVID-19 syndrome in paediatric rheumatology: A scoping review]

[Article in Spanish]
Eduardo Tuta Quintero et al. Rev Colomb Reumatol. .

Abstract
in English, Spanish

Introduction: An increasing number of musculoskeletal clinical manifestations, the onset of diseases and rheumatological manifestations have been seen in the paediatric population surviving COVID-19, however, the medical literature on the subject is limited.

Objective: To explore the available evidence on musculoskeletal symptoms and autoimmune diseases in the paediatric population with post-COVID syndrome.

Methodology: Scoping systematic review in PubMed and Scopus through search strategies. Observational and experimental studies are included in populations under 21 years of age with and without autoimmune diseases, without time limit in English and Spanish.

Results: The 28 documents included: case reports (n = 6), cross-sectional studies (n = 5), prospective cohort studies (n = 5), retrospective cohort (n = 6), case series (n = 6), ambidirectional section (n = 1), randomized controlled trial (n = 1), and longitudinal section study (n = 1). The total study population was 56,738 patients. The most frequent symptoms presented in long COVID-19 are myalgias and arthralgias. The evidence showing a relationship between SARS-CoV-2 infection in the development of musculoskeletal symptoms and autoimmune diseases in the convalescent period is limited.

Conclusions: Myalgias and arthralgias are the most frequent symptoms in long COVID. patients with SARS-CoV-2 infection and a history of rheumatic disease who are undergoing immunomodulatory treatment do not have a dangerous risk of developing severe presentations and/or complications of the disease.

Introducción: En población pediátrica sobreviviente a la COVID-19 se ha visto un creciente número de manifestaciones clínicas musculoesqueléticas, aparición de enfermedades y manifestaciones reumatológicas; sin embargo, la literatura médica sobre el tema es limitada.

Objetivo: Explorar la evidencia disponible sobre los síntomas musculoesqueléticos y las enfermedades autoinmunes en la población pediátrica con síndrome post-COVID.

Metodología: Revisión sistemática exploratoria en PubMed y Scopus por medio de estrategias de búsqueda. Se incluyeron estudios observacionales y experimentales en población menor de 21 años con y sin enfermedades autoinmunes, sin límite de tiempo, en inglés y en español.

Resultados: De los 28 documentos incluidos, se identificaron reportes de caso (n = 6), estudios transversales (n = 5), estudios de cohorte prospectiva (n = 5), cohorte retrospectiva (n = 6), series de casos (n = 3), corte ambidireccional (n = 1), ensayo controlado aleatorizado (n = 1) y estudio de corte longitudinal (n = 1). La población total objeto de estudio fue de 56.738 pacientes. Los síntomas más frecuentes en la COVID-19 prolongada son las mialgias y la artralgias, en tanto que resulta limitada la evidencia que muestre una relación de la infección por SARS-CoV-2 con el desarrollo de síntomas osteomusculares y enfermedades autoinmunes en el periodo de convalecencia.

Conclusiones: Las mialgias y las artralgias son los síntomas más frecuentes en post-COVID. Pacientes con infección por SARS-CoV-2 y antecedente de enfermedad reumática que se encuentren en tratamiento inmunomodulador no tienen un riesgo aumentado para desarrollar presentaciones severas o complicaciones de la enfermedad.

Keywords: Arthralgias; COVID-19; Myalgias; Paediatrics; Rheumatics diseases; SARS-CoV-2.

PubMed Disclaimer

Figures

Figura 1
Figura 1
Flujograma Prisma de las publicaciones incluidas
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. To K.K., Sridhar S., Chiu K.H., Hung D.L., Li X., Hung I.F., et al. Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic. Emerg Microbes Infect. 2021;10:507–535. doi: 10.1080/22221751.2021.1898291. - DOI - PMC - PubMed
    1. Majumder J., Minko T. Recent developments on therapeutic and diagnostic approaches for COVID-19. AAPS J. 2021;23:14. doi: 10.1208/s12248-020-00532-2. - DOI - PMC - PubMed
    1. Aileni M., Rohela G.K., Jogam P., Soujanya S., Zhang B. Biotechnological perspectives to combat the COVID-19 pandemic: Precise diagnostics and inevitable vaccine paradigms. Cells. 2022;11:1182. doi: 10.3390/cells11071182. - DOI - PMC - PubMed
    1. Garg P., Arora U., Kumar A., Wig N. The post-COVID syndrome: How deep is the damage? J Med Virol. 2021;93:673–674. doi: 10.1002/jmv.26465. - DOI - PMC - PubMed
    1. Fink T.T., Marques H.H.S., Gualano B., Lindoso L., Bain V., Astley C., et al. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital. Clinics (Sao Paulo). 2021;76:e35e3511. doi: 10.6061/clinics/2021/e3511. - DOI - PMC - PubMed

LinkOut - more resources