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Review
. 2025 Aug:226:112291.
doi: 10.1016/j.diabres.2025.112291. Epub 2025 Jun 4.

Effect of type-2 diabetes mellitus in long-term mortality in older adults: The NEDICES cohort study

A Corbatón-Anchuelo  1 , S Vega-Quiroga  2 , F Bermejo-Pareja  3 , M Fuentes-Ferrer  4 , M Álvarez-González  5 , J Benito-León  6 , F Hawkins-Carranza  7 , M Serrano-Ríos  8
Affiliations
Review

Effect of type-2 diabetes mellitus in long-term mortality in older adults: The NEDICES cohort study

A Corbatón-Anchuelo et al. Diabetes Res Clin Pract. 2025 Aug.

Abstract

Aims: To describe the mortality associated with type-2 diabetes mellitus (T2DM) in a Spanish elderly population during a 22-year period.

Procedures: Prospective follow-up study (1994-95 to 2017) including 4,998 individuals (≥65 years old at baseline) of three communities (one rural) from central Spain. T2DM diagnosis was recorded during a clinical interview in 1994-95 (self-reported and information from their doctors, including treatment). Mortality incidence until 2017 was checked.

Results: A total of 4,038 subjects were included, with a mean age of 73.6 (±6.6) years; 1,718 (42.5 %) were male and 685 (17.0 %) were diagnosed with T2DM. The mortality rate during follow-up was 85.2 %. Cardiovascular disease was the most frequent cause of death in DM2 subjects, followed by neoplasm. The mortality hazard ratio found for T2DM compared to non-T2DM subjects was 1.29 (1.16-1.45) after adjusting for multiple risk factors. The effect of TDM2 on the mortality rate remained significant in men (HR:1.27; CI 95 %:1.08-1.49;p = 0.005) and women (HR:1.32; CI 95 %:1.14-1.53;p < 0.001), with no differences between sexes (p = 0.705).

Main conclusion: The sustained reduction in T2DM elderly Spanish subjects' life expectancy address the necessity of community interventions and campaigns regarding lifestyle modifications and reinforce the need for an adequate and regular TDM2 subjects clinical follow-up.

Keywords: Elderly; Long-term mortality; T2DM (type 2 diabetes mellitus).

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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