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. 2025 Jun 5;11(2):e005504.
doi: 10.1136/rmdopen-2025-005504.

Long-term maintenance of remission with spacing of rituximab infusions based on the individualised patient risk profile in ANCA-associated vasculitis: a pilot study

Alice Bartoletti  1   2 , Alessandra Milanesi  3   2   4 , Sara Monti  2   5   6 , Carlomaurizio Montecucco  3   2 , Paolo Delvino  3   7
Affiliations

Long-term maintenance of remission with spacing of rituximab infusions based on the individualised patient risk profile in ANCA-associated vasculitis: a pilot study

Alice Bartoletti et al. RMD Open. .
No abstract available

Keywords: Granulomatosis with polyangiitis; Recurrence; Rituximab; Treatment; Vasculitis.

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Conflict of interest statement

Competing interests: PD reports a relationship with GlaxoSmithKline (speaking and lecture fees). SM reports a relationship with Vifor Pharma (speaking and lecture fees) and AstraZeneca Pharmaceuticals (speaking and lecture fees). AB, AM and CM report no conflict of interest.

References

    1. Hellmich B, Sanchez-Alamo B, Schirmer JH, et al. EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update. Ann Rheum Dis. 2023 doi: 10.1136/ard-2024-225606. - DOI - PubMed
    1. Monti S, Brandolino F, Milanesi A, et al. Novel Therapies for ANCA-associated Vasculitis. Curr Rheumatol Rep. 2021;23:38. doi: 10.1007/s11926-021-01010-0. - DOI - PubMed
    1. Charles P, Perrodeau É, Samson M, et al. Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Trial. Ann Intern Med. 2020;173:179–87. doi: 10.7326/M19-3827. - DOI - PubMed
    1. Delestre F, Charles P, Karras A, et al. Rituximab as maintenance therapy for ANCA-associated vasculitides: pooled analysis and long-term outcome of 277 patients included in the MAINRITSAN trials. Ann Rheum Dis. 2023 - PubMed
    1. Liberatore J, Nguyen Y, Hadjadj J, et al. Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study. J Autoimmun. 2024;142:103130. doi: 10.1016/j.jaut.2023.103130. - DOI - PubMed

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