Ovarian cancer risk and survival according to tumor sex hormone receptor expression: An ovarian Cancer association consortium and ovarian tumor tissue analysis consortium pooled analysis

Zhuxuan Fu¹, Lauren Borho², Sarah E Taylor², Linda E Kelemen³, Anna DeFazio⁴, Penelope M Webb⁵, Martin Köbel⁶, Nicola S Meagher⁷, Renhua Na⁵, Antonis C Antoniou⁸, Alison H Brand⁹, Catherine J Kennedy¹⁰, Nikilyn Nevins¹⁰, Paul D P Pharoah¹¹, Yurii B Shvetsov¹², Stacey J Winham¹³, Jennifer Alsop¹⁴, Matthias W Beckmann¹⁵, Adelyn Bolithon¹⁶, Jessica Boros¹⁰, David D L Bowtell¹⁷, James D Brenton¹⁸, Michael E Carney¹⁹, Anita Chudecka-Głaz²⁰, Linda S Cook²¹, Cezary Cybulski²², Peter A Fasching¹⁵, Sian Fereday¹⁷, Renée T Fortner²³, María J García²⁴, Ellen L Goode²⁵, Marc T Goodman²⁶, Jacek Gronwald²⁷, Arndt Hartmann¹⁵, Brenda Y Hernandez¹², Estrid Høgdall²⁸, David G Huntsman²⁹, Allan Jensen³⁰, Mercedes Jimenez-Linan³¹, Janine M Joseph³², Beth Y Karlan³³, Ewa Kaznowska³⁴, Susanne K Kjaer³⁵, Tomasz Kluz³⁶, Jennifer M Koziak³⁷, Jenny Lester³³, Teri A Longacre³⁸, Maria Lycke³⁹, Valerie McGuire⁴⁰, Kirsten B Moysich³², Rachel A Murphy⁴¹, Sandra Orsulic³³, Susan J Ramus¹⁶, Cristina Rodríguez-Antona⁴², Joseph H Rothstein⁴³, Spinder Samra⁴⁴, Weiva Sieh⁴⁵, Helen Steed⁴⁶, Karin Sundfeldt⁴⁷, Aline Talhouk⁴⁸, Jan Uciński²⁰, Chen Wang¹³, Nicolas Wentzensen⁴⁹, Alice S Whittemore⁵⁰, Lynne R Wilkens¹², Thomas Songer⁵¹, Maria Mori Brooks⁵¹, Lu Tang⁵², Francesmary Modugno⁵³

Affiliations

¹ Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA 15213, USA; St. Luke's Mid America Heart Institute. St Luke's Health System. Kansas City, MO, USA.
² Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences. University of Pittsburgh School of Medicine. Pittsburgh, PA 15213, USA.
³ South Carolina Department of Public Health. Columbia, SC, USA.
⁴ Centre for Cancer Research. The Westmead Institute for Medical Research. Sydney, New South Wales 2145, Australia; Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Gynaecological Oncology. Westmead Hospital. Sydney, New South Wales 2145, Australia; The Daffodil Centre, The University of Sydney. A Joint Venture with Cancer Council NSW. Sydney, New South Wales 2006, Australia.
⁵ Population Health Program. QIMR Berghofer. Brisbane, Queensland 4006, Australia; School of Public Health. The University of Queensland. Brisbane 4006, Australia.
⁶ Department of Pathology and Laboratory Medicine. University of Calgary, Foothills Medical Center. Calgary, AB T2N 2T9, Canada.
⁷ The Daffodil Centre, The University of Sydney. A Joint Venture with Cancer Council NSW. Sydney, New South Wales 2006, Australia; School of Clinical Medicine, UNSW Medicine and Health. University of NSW Sydney. Sydney, New South Wales 2052, Australia.
⁸ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care. University of Cambridge. Cambridge CB1 8RN, UK.
⁹ Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Gynaecological Oncology. Westmead Hospital. Sydney, New South Wales 2145, Australia.
¹⁰ Centre for Cancer Research. The Westmead Institute for Medical Research. Sydney, New South Wales 2145, Australia; Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Gynaecological Oncology. Westmead Hospital. Sydney, New South Wales 2145, Australia.
¹¹ Department of Computational Biomedicine. Cedars-Sinai Medical Center. West Hollywood, CA 90069, USA.
¹² University of Hawaii Cancer Center. Honolulu, HI, USA.
¹³ Department of Quantitative Health Sciences, Division of Computational Biology. Mayo Clinic. Rochester, MN 55905, USA.
¹⁴ Center for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
¹⁵ Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg. University Hospital Erlangen. Erlangen 91054, Germany.
¹⁶ School of Clinical Medicine, UNSW Medicine and Health. University of NSW Sydney. Sydney, New South Wales 2052, Australia; Adult Cancer Program, Lowy Cancer Research Centre. University of NSW Sydney. Sydney, New South Wales 2052, Australia.
¹⁷ Peter MacCallum Cancer Centre. Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology. The University of Melbourne. Parkville, Victoria 3010, Australia.
¹⁸ Cancer Research UK Cambridge Institute, University of Cambridge. Cambridge CB2 0RE, UK.
¹⁹ Department of Obstetrics and Gynecology, John A. Burns School of Medicine. University of Hawaii. Honolulu, HI, USA.
²⁰ Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents. Pomeranian Medical University. Szczecin 70-111, Poland.
²¹ Epidemiology, School of Public Health, University of Colorado. Aurora, CO, USA; Community Health Sciences. University of Calgary. Calgary, AB, Canada.
²² International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
²³ Division of Cancer Epidemiology. German Cancer Research Center (DKFZ). Heidelberg 69120, Germany; Department of Research, Cancer Registry of Norway. Norwegian Institute of Public Health. Oslo, Norway.
²⁴ Genomic Biomarkers and Precision Oncology Laboratory, Cancer Department. Sols-Morreale Biomedical Research Institute (IIBM), CSIC-UAM. Madrid, Spain.
²⁵ Department of Quantitative Health Sciences, Division of Epidemiology. Mayo Clinic. Rochester, MN 55905, USA.
²⁶ Cancer Prevention and Control Program, Cedars-Sinai Cancer. Cedars-Sinai Medical Center. Los Angeles, CA 90048, USA.
²⁷ Department of Genetics and Pathology. Pomeranian Medical University. Szczecin 71-252, Poland.
²⁸ Department of Pathology, Herlev Hospital. University of Copenhagen. Copenhagen DK-2100, Denmark.
²⁹ Department of Obstetrics and Gynecology. University of British Columbia. Vancouver, BC V5Z 1L3, Canada; Department of Molecular Oncology. BC Cancer Research Centre. Vancouver, BC V5Z 4E6, Canada.
³⁰ Department of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen DK-2100, Denmark.
³¹ Department of Histopathology. Addenbrooke's Hospital. Cambridge, UK.
³² Department of Cancer Prevention and Control. Roswell Park Comprehensive Cancer Center. Buffalo, NY 14263, USA.
³³ David Geffen School of Medicine, Department of Obstetrics and Gynecology. University of California at Los Angeles. Los Angeles, CA 90095, USA.
³⁴ Department of Pathology, Faculty of Medicine, University of Rzeszow. 35-559 Rzesow, Poland.
³⁵ Department of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen DK-2100, Denmark; Department of Gynaecology, Rigshospitalet. University of Copenhagen. Copenhagen DK-2100, Denmark.
³⁶ Department of Gynecology, Gynecology Oncology and Obstetrics. Institute of Medical Sciences, Medical College of Rzeszow University. Rzesz-w: Poland.
³⁷ Department of Obstetrics and Gynaecology. University of Calgary. Calgary, AB, Canada.
³⁸ Department of Pathology. Stanford University School of Medicine. Stanford, CA 94305, USA.
³⁹ Department of Obstetrics and Gynecology, Institute of Clinical Science. Sahlgrenska University hospital, University of Gothenburg. Gothenburg: Sweden.
⁴⁰ Department of Epidemiology and Population Health. Stanford University School of Medicine. Stanford, CA 94305, USA; Department of Epidemiology and Biostatistics. University of California San Francisco. San Francisco, CA 94158, USA.
⁴¹ School of Population and Public Health. University of British Columbia. Vancouver, BC V6T 1Z4, Canada; Cancer Control Research. BC Cancer Agency. Vancouver, BC V5Z 1L3, Canada.
⁴² Pharmacogenomics and Tumour Biomarkers Laboratory, Cancer Department. Sols-Morreale Biomedical Research Institute (IIBM), CSIC-UAM. Madrid, Spain; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III. Madrid 28029, Spain.
⁴³ Department of Epidemiology. University of Texas MD Anderson Cancer Center. Houston, TX 77030, USA; Department of Population Health Science and Policy. Icahn School of Medicine at Mount Sinai. New York, NY 10029, USA.
⁴⁴ Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Tissue Pathology and Diagnostic Oncology, ICPMR West Mead Hospital, New South Wales, Australia.
⁴⁵ Department of Epidemiology. University of Texas MD Anderson Cancer Center. Houston, TX 77030, USA; Department of Genetics and Genomic Sciences. Icahn School of Medicine at Mount Sinai. New York, NY 10029, USA.
⁴⁶ Division of Gynecologic Oncology, Department of Obstetrics and Gynecology. University of Alberta. Edmonton, Alberta T5H 3V9, Canada; Section of Gynecologic Oncology Surgery, North Zone. Alberta Health Services. Edmonton, Alberta, Canada.
⁴⁷ Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Center for Cancer Research. University of Gothenburg. Gothenburg, Sweden.
⁴⁸ Department of Obstetrics and Gynecology. University of British Columbia. Vancouver, BC V5Z 1L3, Canada; British Columbia's Gynecological Cancer Research Team (OVCARE). University of British Columbia, BC Cancer, and Vancouver General Hospital. Vancouver, BC V5Z 4E6, Canada.
⁴⁹ Division of Cancer Epidemiology and Genetics. National Cancer Institute. Bethesda, MD 20892, USA.
⁵⁰ Department of Epidemiology and Population Health. Stanford University School of Medicine. Stanford, CA 94305, USA; Department of Biomedical Data Science. Stanford University School of Medicine. Stanford, CA 94305, USA.
⁵¹ Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA 15213, USA.
⁵² Department of Biostatistics. University of Pittsburgh Graduate School of Public Health. Pittsburgh, PA, USA.
⁵³ Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA 15213, USA; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences. University of Pittsburgh School of Medicine. Pittsburgh, PA 15213, USA; Women's Cancer Research Center. Magee-Womens Research Institute and Hillman Cancer Center. Pittsburgh 15213, PA, USA; Department of Biomedical Informatics. University of Pittsburgh School of Medicine. Pittsburgh, PA 15213, USA. Electronic address: modugnof@upmc.edu.

PMID: 40482607
PMCID: PMC12885142
DOI: 10.1016/j.ygyno.2025.05.013

Ovarian cancer risk and survival according to tumor sex hormone receptor expression: An ovarian Cancer association consortium and ovarian tumor tissue analysis consortium pooled analysis

Zhuxuan Fu et al. Gynecol Oncol. 2025 Jul.

. 2025 Jul:198:112-129.

doi: 10.1016/j.ygyno.2025.05.013. Epub 2025 Jun 6.

Authors

Affiliations

¹ Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA 15213, USA; St. Luke's Mid America Heart Institute. St Luke's Health System. Kansas City, MO, USA.
² Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences. University of Pittsburgh School of Medicine. Pittsburgh, PA 15213, USA.
³ South Carolina Department of Public Health. Columbia, SC, USA.
⁴ Centre for Cancer Research. The Westmead Institute for Medical Research. Sydney, New South Wales 2145, Australia; Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Gynaecological Oncology. Westmead Hospital. Sydney, New South Wales 2145, Australia; The Daffodil Centre, The University of Sydney. A Joint Venture with Cancer Council NSW. Sydney, New South Wales 2006, Australia.
⁵ Population Health Program. QIMR Berghofer. Brisbane, Queensland 4006, Australia; School of Public Health. The University of Queensland. Brisbane 4006, Australia.
⁶ Department of Pathology and Laboratory Medicine. University of Calgary, Foothills Medical Center. Calgary, AB T2N 2T9, Canada.
⁷ The Daffodil Centre, The University of Sydney. A Joint Venture with Cancer Council NSW. Sydney, New South Wales 2006, Australia; School of Clinical Medicine, UNSW Medicine and Health. University of NSW Sydney. Sydney, New South Wales 2052, Australia.
⁸ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care. University of Cambridge. Cambridge CB1 8RN, UK.
⁹ Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Gynaecological Oncology. Westmead Hospital. Sydney, New South Wales 2145, Australia.
¹⁰ Centre for Cancer Research. The Westmead Institute for Medical Research. Sydney, New South Wales 2145, Australia; Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Gynaecological Oncology. Westmead Hospital. Sydney, New South Wales 2145, Australia.
¹¹ Department of Computational Biomedicine. Cedars-Sinai Medical Center. West Hollywood, CA 90069, USA.
¹² University of Hawaii Cancer Center. Honolulu, HI, USA.
¹³ Department of Quantitative Health Sciences, Division of Computational Biology. Mayo Clinic. Rochester, MN 55905, USA.
¹⁴ Center for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
¹⁵ Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg. University Hospital Erlangen. Erlangen 91054, Germany.
¹⁶ School of Clinical Medicine, UNSW Medicine and Health. University of NSW Sydney. Sydney, New South Wales 2052, Australia; Adult Cancer Program, Lowy Cancer Research Centre. University of NSW Sydney. Sydney, New South Wales 2052, Australia.
¹⁷ Peter MacCallum Cancer Centre. Melbourne, Victoria 3000, Australia; Sir Peter MacCallum Department of Oncology. The University of Melbourne. Parkville, Victoria 3010, Australia.
¹⁸ Cancer Research UK Cambridge Institute, University of Cambridge. Cambridge CB2 0RE, UK.
¹⁹ Department of Obstetrics and Gynecology, John A. Burns School of Medicine. University of Hawaii. Honolulu, HI, USA.
²⁰ Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents. Pomeranian Medical University. Szczecin 70-111, Poland.
²¹ Epidemiology, School of Public Health, University of Colorado. Aurora, CO, USA; Community Health Sciences. University of Calgary. Calgary, AB, Canada.
²² International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
²³ Division of Cancer Epidemiology. German Cancer Research Center (DKFZ). Heidelberg 69120, Germany; Department of Research, Cancer Registry of Norway. Norwegian Institute of Public Health. Oslo, Norway.
²⁴ Genomic Biomarkers and Precision Oncology Laboratory, Cancer Department. Sols-Morreale Biomedical Research Institute (IIBM), CSIC-UAM. Madrid, Spain.
²⁵ Department of Quantitative Health Sciences, Division of Epidemiology. Mayo Clinic. Rochester, MN 55905, USA.
²⁶ Cancer Prevention and Control Program, Cedars-Sinai Cancer. Cedars-Sinai Medical Center. Los Angeles, CA 90048, USA.
²⁷ Department of Genetics and Pathology. Pomeranian Medical University. Szczecin 71-252, Poland.
²⁸ Department of Pathology, Herlev Hospital. University of Copenhagen. Copenhagen DK-2100, Denmark.
²⁹ Department of Obstetrics and Gynecology. University of British Columbia. Vancouver, BC V5Z 1L3, Canada; Department of Molecular Oncology. BC Cancer Research Centre. Vancouver, BC V5Z 4E6, Canada.
³⁰ Department of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen DK-2100, Denmark.
³¹ Department of Histopathology. Addenbrooke's Hospital. Cambridge, UK.
³² Department of Cancer Prevention and Control. Roswell Park Comprehensive Cancer Center. Buffalo, NY 14263, USA.
³³ David Geffen School of Medicine, Department of Obstetrics and Gynecology. University of California at Los Angeles. Los Angeles, CA 90095, USA.
³⁴ Department of Pathology, Faculty of Medicine, University of Rzeszow. 35-559 Rzesow, Poland.
³⁵ Department of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen DK-2100, Denmark; Department of Gynaecology, Rigshospitalet. University of Copenhagen. Copenhagen DK-2100, Denmark.
³⁶ Department of Gynecology, Gynecology Oncology and Obstetrics. Institute of Medical Sciences, Medical College of Rzeszow University. Rzesz-w: Poland.
³⁷ Department of Obstetrics and Gynaecology. University of Calgary. Calgary, AB, Canada.
³⁸ Department of Pathology. Stanford University School of Medicine. Stanford, CA 94305, USA.
³⁹ Department of Obstetrics and Gynecology, Institute of Clinical Science. Sahlgrenska University hospital, University of Gothenburg. Gothenburg: Sweden.
⁴⁰ Department of Epidemiology and Population Health. Stanford University School of Medicine. Stanford, CA 94305, USA; Department of Epidemiology and Biostatistics. University of California San Francisco. San Francisco, CA 94158, USA.
⁴¹ School of Population and Public Health. University of British Columbia. Vancouver, BC V6T 1Z4, Canada; Cancer Control Research. BC Cancer Agency. Vancouver, BC V5Z 1L3, Canada.
⁴² Pharmacogenomics and Tumour Biomarkers Laboratory, Cancer Department. Sols-Morreale Biomedical Research Institute (IIBM), CSIC-UAM. Madrid, Spain; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III. Madrid 28029, Spain.
⁴³ Department of Epidemiology. University of Texas MD Anderson Cancer Center. Houston, TX 77030, USA; Department of Population Health Science and Policy. Icahn School of Medicine at Mount Sinai. New York, NY 10029, USA.
⁴⁴ Faculty of Medicine and Health. The University of Sydney. Sydney, New South Wales 2006, Australia.; Department of Tissue Pathology and Diagnostic Oncology, ICPMR West Mead Hospital, New South Wales, Australia.
⁴⁵ Department of Epidemiology. University of Texas MD Anderson Cancer Center. Houston, TX 77030, USA; Department of Genetics and Genomic Sciences. Icahn School of Medicine at Mount Sinai. New York, NY 10029, USA.
⁴⁶ Division of Gynecologic Oncology, Department of Obstetrics and Gynecology. University of Alberta. Edmonton, Alberta T5H 3V9, Canada; Section of Gynecologic Oncology Surgery, North Zone. Alberta Health Services. Edmonton, Alberta, Canada.
⁴⁷ Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Center for Cancer Research. University of Gothenburg. Gothenburg, Sweden.
⁴⁸ Department of Obstetrics and Gynecology. University of British Columbia. Vancouver, BC V5Z 1L3, Canada; British Columbia's Gynecological Cancer Research Team (OVCARE). University of British Columbia, BC Cancer, and Vancouver General Hospital. Vancouver, BC V5Z 4E6, Canada.
⁴⁹ Division of Cancer Epidemiology and Genetics. National Cancer Institute. Bethesda, MD 20892, USA.
⁵⁰ Department of Epidemiology and Population Health. Stanford University School of Medicine. Stanford, CA 94305, USA; Department of Biomedical Data Science. Stanford University School of Medicine. Stanford, CA 94305, USA.
⁵¹ Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA 15213, USA.
⁵² Department of Biostatistics. University of Pittsburgh Graduate School of Public Health. Pittsburgh, PA, USA.
⁵³ Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA 15213, USA; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences. University of Pittsburgh School of Medicine. Pittsburgh, PA 15213, USA; Women's Cancer Research Center. Magee-Womens Research Institute and Hillman Cancer Center. Pittsburgh 15213, PA, USA; Department of Biomedical Informatics. University of Pittsburgh School of Medicine. Pittsburgh, PA 15213, USA. Electronic address: modugnof@upmc.edu.

PMID: 40482607
PMCID: PMC12885142
DOI: 10.1016/j.ygyno.2025.05.013

Abstract

Objective: Many epithelial ovarian cancer (EOC) risk factors relate to sex hormones. The association between these factors and the expression of androgen receptor (AR), estrogen receptor-α (ER), and progesterone receptor (PR) in tumors is unknown.

Method: We linked epidemiologic, AR/ER/PR tumor expression, and survival data from 19 studies in the Ovarian Cancer Association Consortium (OCAC; 4762 cases, 20,888 controls) and the Ovarian Tumor Tissue Analysis (OTTA) consortium (5737 cases). We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) between hormonally-linked factors and tumor AR/ER/PR expression using polytomous logistic regression. We assessed survival by AR/ER/PR tumor expression overall and by histotype using Kaplan-Meier curves and Cox proportional hazards models.

Results: Overweight/obesity was associated with higher risk of ER- tumors (OR:1.53, 95 % I:1.18-1.98). Hysterectomy was associated with greater risk of ER+ tumors (OR:4.99, 95 % CI:4.27-5.83), which varied by AR expression (P_heter=0.003). Postmenopause was associated with a higher risk of PR- tumors (OR 1.52, 95 % CI 1.26-1.83), which varied based by AR (P_heter < 0.001) and ER (P_heter < 0.001) expression. Gravidity, oral contraception duration, and breastfeeding duration showed differing dose-response relationships according to AR/ER/PR expression. Hormone therapy use, postmenopause, physical inactivity, and being obese/overweight prior to diagnosis were differentially associated with survival based on AR/ER/PR expression and histotype.

Conclusion: EOC has varying risk and prognostic profiles depending on both histotype and AR/ER/PR expression. Biological mechanisms underlying the association between hormonally-linked factors and EOC need to be studied by both histotypes and by AR, ER, and PR expression.

Keywords: Epithelial ovarian cancer; Hormonal factors; Hormone receptor; Risk; Survival; androgen receptor; estrogen receptor; progesterone receptor.

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Conflict of interest statement

Declaration of competing interest Jessica Boros: Cancer Institute New South Wales, National Health and Medical Research Council of Australia, Department of Gynecological Oncology, Westmead Hospital, NSW, The Westmead Institute for Medical Research. Alison Brand: Board of Directors of ANZGOG and GCIG, Data Safety Management Board for DEBULK. Anna DeFazio: Research support from AstraZeneca, Illumina. Sian Fereday: AstraZeneca Pty Ltd. – Research Grant to AOCS. Maria J. Garcia: Proyect Grant from Ministerio de Ciencia, Innovación y Universidades. Ellen Goode: Mayo Foundation; Minnesota. Arndt Hartmann: AstraZeneca, Biocartis, Cepheid, Gilead, Illumina, Janssen, Novartis, Owkin, Qiagen, QUIP GmbH – payments to the institution. Beth Karlan: American Cancer Society Early Detection Professorship (SIOP-06-258-01-COUN); UCLA Clinical and Translational Science Institute – Precision Health; Independent Data Monitoring Committee – GRAIL PATHFINDER; Scientific Advisor to Ovarian Cancer Research Alliance (OCRA) and American Cancer Society (ACS) BrightEdge. Catherine Jane Kennedy: Australian National Health and Medical Research Council, Cancer Institute NSW – grant payments to my institution. Martin Kobel: Payments from Astra Zeneca, GSK, Merck, AbbVie, Helix biopharma. Renhua Na: NHMRC Program Grant (GNT1073898). Niklyn Nevins: Research support from Illumina. Christina Rodriguez-Antona: Grant PID2021-1283120B-100, funded by MCIN/AEI/10.13039/501100011033 and by ERDF A way of making Europe. Penelope M. Webb: U.S. Army Medical Research and Material Command, National Health & Medical Research Council of Australia, Cancer Councils of New South Wales, Victoria, Queensland, South Australia and Tasmania and Cancer Foundation of Western Australia – Grants to institution. All other authors declare no conflicts of interest.

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Ovarian cancer risk and survival according to tumor sex hormone receptor expression: An ovarian Cancer association consortium and ovarian tumor tissue analysis consortium pooled analysis

Affiliations

Ovarian cancer risk and survival according to tumor sex hormone receptor expression: An ovarian Cancer association consortium and ovarian tumor tissue analysis consortium pooled analysis

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Research Materials