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. 2025 May 1;17(5):e560-e568.
doi: 10.4317/jced.62666. eCollection 2025 May.

A comparative study of platelet-rich fibrin plugs versus biphasic calcium phosphate in treating infrabony defects in patients with periodontitis: Insights from a randomized controlled trial

Parkavi Arumugam  1 , Mala Dixit Baburaj  2 , Pradeep Kumar Yadalam  1 , Carlos M Ardila  1   3
Affiliations

A comparative study of platelet-rich fibrin plugs versus biphasic calcium phosphate in treating infrabony defects in patients with periodontitis: Insights from a randomized controlled trial

Parkavi Arumugam et al. J Clin Exp Dent. .

Abstract

Background: Bone grafts and growth factors have been utilized to manage infrabony defects. Platelet-rich fibrin (PRF) has demonstrated significant potential due to its sustained release of growth factors and autologous nature. This study aimed to conduct a clinical and radiographic comparison of PRF plug as a sole graft versus biphasic calcium phosphate (BCP) (SybografTM - Plus) in treating infrabony defects in patients with chronic periodontitis.

Material and methods: Forty patients were recruited for this randomized controlled interventional study and assigned to Group A or B via computer randomization. After open flap debridement, the infrabony defects were grafted with a PRF plug in Group A (n=20) and BCP in Group B (n=20). Clinical parameters, including the Plaque Index (PI) and Gingival Index (GI), were measured at baseline, one month, three months, and six months post-surgery while Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) were measured at baseline, three months, and six months post-surgery. The radiographic depth of defect and bone fill were assessed at baseline, immediately, and six months post-surgery. Parametric tests (t-test for two groups, ANOVA for three or more groups) were employed for statistical analysis.

Results: At six months post-surgery, the differences in terms of PI (p-value - 0.3886), GI (p-value - 0.1633), PPD (p-value - 0.3240), CAL (p-value - 0.2493), and radiographic bone fill (p-value - 0.8168) between both groups were not statistically significant.

Conclusions: PRF plug as a sole grafting material has shown promising results for periodontal regeneration comparable to BCP in the treatment of infrabony defects in patients with chronic periodontitis. Key words:Periodontitis, Infrabony defects, Platelet-rich fibrin, Biphasic calcium phosphate, Periodontal regeneration, Radiographic bone fill.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Treatment of infrabony defects with PRF plug.
Figure 2
Figure 2
Treatment of infrabony defects with BCP.
See this image and copyright information in PMC

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