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. 2025 Apr;71(4):292-296.
doi: 10.1159/000544121. Epub 2025 Feb 13.

Electrocardiographic markers in Motoric Cognitive Risk syndrome

Joe Verghese  1 , Sharika Sreeram  2 , Vijin Joseph  3 , Dristi Adhikari  4 , Alben Sigamani  5 , Helena M Blumen  1 , V G Pradeep Kumar  4 , Emmeline Ayers  1
Affiliations

Electrocardiographic markers in Motoric Cognitive Risk syndrome

Joe Verghese et al. Gerontology. 2025 Apr.

Abstract

Introduction: Presence of cardiovascular disease is linked to the prevalence and incidence of Motoric Cognitive Risk syndrome (MCR), a pre-dementia syndrome characterized by cognitive complaints and slow gait. Electrocardiograms (ECGs) may offer a cost-effective, non-invasive, and reliable method for detecting cardiovascular abnormalities in individuals with MCR. This approach can not only diagnose cardiovascular disease but also facilitate timely interventions to prevent further cognitive decline in MCR cases.

Methods: We examined the association of ECG abnormalities with prevalent MCR in 451 older adults with ECGs participating in the Kerala Einstein Study (KES), based in Indian state of Kerala. Logistic regression analysis adjusted for age and sex were used to examine associations, and reported as odds ratios (OR) with 95% confidence intervals (CI).

Results: ECG abnormalities were present in 191 (42.4%) participants. Of the 43 participants diagnosed with MCR, 23 (53.5%) had ECG abnormalities. Abnormal Q waves (OR 5.1, 95% CI 1.7-14.9) and heart block (OR 6.0, 95% CI 2.1-17.4) were more common in individuals with MCR compared to controls. There were no statistically significant group differences in the prevalence of other ECG abnormalities.

Conclusion: ECG abnormalities are common in MCR patients, and can be considered for cardiovascular disease risk-stratification in MCR cases.

Keywords: Electrocardiography; cardiovascular disease; dementia; epidemiology; motoric cognitive risk syndrome.

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Conflict of interest statement

Conflict of Interest Statement “The authors have no conflicts of interest to declare.”

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