Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 May 7;17(5):e83633.
doi: 10.7759/cureus.83633. eCollection 2025 May.

The Impact of CD34+ Cells on Wound Healing Outcomes in Oral and Maxillofacial Surgery: A Systematic Review of Randomized Controlled Trials

Tharanikumar Sivakumar  1 , Chandrasekaran Krithika  2 , Chitathoor Sridhar  3 , Elaveyini U  4 , Parthiban Manohar  5 , Nachiappan S  6
Affiliations
Review

The Impact of CD34+ Cells on Wound Healing Outcomes in Oral and Maxillofacial Surgery: A Systematic Review of Randomized Controlled Trials

Tharanikumar Sivakumar et al. Cureus. .

Abstract

Despite significant advancements in surgery and biomaterials science, delayed healing and related complications remain major challenges. Emerging studies have highlighted the promising role of CD34+ cells in promoting accelerated wound healing. This systematic review aims to comprehensively evaluate the impact of CD34+ cells on healing outcomes in oral and maxillofacial surgery. A thorough search was conducted using PubMed and the Cochrane Library (CENTRAL via Ovid), complemented by manual screening of additional articles. Only randomized controlled trials (RCTs) involving systemic or local administration of CD34+ cells were included. Healing time and complication rates were the primary outcomes assessed. The review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and employed the Cochrane Risk of Bias 2 tool for quality assessment. Three relevant RCTs met the inclusion criteria. Regardless of the assessed risk of bias, all studies supported the potential therapeutic benefits of CD34+ cell-based interventions in oral and maxillofacial surgery. However, the findings also revealed significant gaps in current knowledge within this field. Overall, CD34+ cells show strong potential in enhancing wound healing in oral and maxillofacial procedures. This review lays the groundwork for future regenerative strategies aimed at optimizing surgical outcomes in this specialized area. The application of CD34+ cells in such contexts appears to be technically justified.

Keywords: acute and chronic wounds; acute wounds; cd34; chronic wounds; healing; maxillofacial; rct; regeneration.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. PRISMA flow diagram of the study selection process
PRISMA, Preferred Reporting Items for Systematic reviews and Meta-Analyses
Figure 2
Figure 2. Risk of bias assessment for the included articles
See this image and copyright information in PMC

References

    1. Prakash P, Bahri R, Bhandari SK. Beauty - Cosmetic Science, Cultural Issues and Creative Developments. Rijeka: IntechOpen; 2021. Maxillofacial defects: impact on psychology and esthetics.
    1. Cutaneous wound healing: an update from physiopathology to current therapies. Gushiken LF, Beserra FP, Bastos JK, Jackson CJ, Pellizzon CH. Life (Basel) 2021;11:665. - PMC - PubMed
    1. Schultz GS, Chin GA, Moldawer L, et al. Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists [Internet] Adelaide (AU): University of Adelaide Press; 2011. Principles of wound healing. - PubMed
    1. Transition from inflammation to proliferation: a critical step during wound healing. Landen NX, Li D, Stahle M. Cell Mol Life Sci. 2016;73:3861–3885. - PMC - PubMed
    1. Innovative treatment strategies to accelerate wound healing: trajectory and recent advancements. Kolimi P, Narala S, Nyavanandi D, Youssef AA, Dudhipala N. Cells. 2022;11:2439. - PMC - PubMed

LinkOut - more resources