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Meta-Analysis
. 2025 May 23:16:1576845.
doi: 10.3389/fimmu.2025.1576845. eCollection 2025.

Prognostic value of systemic inflammation response index in patients with glioma: a meta-analysis

Yizhen Jiang  1 , Lin Zhou  2
Affiliations
Meta-Analysis

Prognostic value of systemic inflammation response index in patients with glioma: a meta-analysis

Yizhen Jiang et al. Front Immunol. .

Abstract

Background: The systemic inflammation response index (SIRI) has been investigated for its prognostic relevance in patients with glioma; however, findings remain inconsistent. Therefore, this meta-analysis aimed to clarify the prognostic value of SIRI in glioma.

Methods: PubMed, Web of Science, Embase, Cochrane Library, and CNKI were systematically searched through December 28, 2024. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to assess the association between SIRI and glioma prognosis.

Results: A total of 10 studies including 1,942 participants were analyzed. Elevated SIRI was significantly associated with poorer overall survival (OS) (HR=1.67, 95% CI=1.46-1.91, p<0.001) and shorter progression-free survival (PFS) (HR=1.80, 95% CI=1.29-2.52, p=0.001). Subgroup analyses indicated that the prognostic value of SIRI for OS and PFS was consistent regardless of sample size, pathological subtype, cutoff value, or type of survival analysis (p<0.05). Sensitivity and publication bias analyses confirmed the robustness of the results.

Conclusion: This meta-analysis demonstrates that high SIRI is a significant predictor of OS and PFS in patients with glioma. SIRI may serve as a promising prognostic biomarker in glioma-related clinical practice.

Keywords: biomarker; glioma; meta-analysis; prognosis; systemic inflammation response index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram of study selection.
Figure 2
Figure 2
Forest plots of HR with 95% CI for correlation between SIRI and OS in patients with glioma.
Figure 3
Figure 3
Forest plots of HR with 95% CI for correlation between SIRI and PFS in patients with glioma.
Figure 4
Figure 4
Sensitivity analysis. (A) OS and (B) PFS.
Figure 5
Figure 5
Publication bias by Begg’s test and Egger’s test. (A) Begg’s test for OS, p=0.371; (B) Egger’s test for OS, p=0.408; (C) Begg’s test for PFS, p=0.127; and (D) Egger’s test for PFS, p=0.225.
See this image and copyright information in PMC

References

    1. Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, et al. . Glioma. Nat Rev Dis Primers. (2024) 10:33. doi: 10.1038/s41572-024-00516-y - DOI - PubMed
    1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. . Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J clinicians. (2024) 74:229–63. doi: 10.3322/caac.21834 - DOI - PubMed
    1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. . The 2007 WHO classification of tumours of the central nervous system. Acta neuropathologica. (2007) 114:97–109. doi: 10.1007/s00401-007-0243-4 - DOI - PMC - PubMed
    1. Komori T. Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System. Lab investigation; A J Tech Methods Pathol. (2022) 102:126–33. doi: 10.1038/s41374-021-00667-6 - DOI - PubMed
    1. Schaff LR, Mellinghoff IK. Glioblastoma and other primary brain Malignancies in adults: A review. Jama. (2023) 329:574–87. doi: 10.1001/jama.2023.0023 - DOI - PMC - PubMed