Personalized therapeutic approaches for improved glycemic outcomes in type 2 diabetes

Abstract

Managing type 2 diabetes mellitus remains a significant challenge, particularly for individuals with persistently poor glycemic control. Although inadequate glycemic regulation is a well-established public health concern and a major contributor to diabetes-related complications, evidence on the effectiveness of intensive and supportive interventions across diverse patient subgroups is scarce. This editorial examines findings from a prospective study evaluating the influence of glycemic history on treatment outcomes in poorly controlled diabetes. The study highlights that personalized care models outperform generalized approaches by addressing the unique trajectories of glycemic deterioration. Newly diagnosed patients demonstrated the most favorable response to intervention, while those with consistently elevated glycated hemoglobin (≥ 10%) faced the greatest challenges in achieving glycemic control. These findings underscore the limitations of a one-size-fits-all strategy, reinforcing the need for patient-centered care that integrates individualized monitoring and timely intervention. Diabetes management requires prioritizing personalized treatment strategies that mitigate therapeutic inertia and ensure equitable, effective care for all patients.

Keywords: Diabetes control; Glycated hemoglobin improvement; Glycemic trajectories; Metabolic challenges; Personalized treatment; Therapeutic inertia.