Irregularities in the IARC Working Group Evaluation of Ramazzini Institute Aspartame Studies

Affiliations

¹ Global Observatory on Planetary Health, Boston College, Chestnut Hill, MA, USA and Centre Scientifique de Monaco, Monaco.
² Global Observatory on Planetary Health, Connell School of Nursing, Boston College, Chestnut Hill, MA, USA, and ISGlobal, Barcelona, Spain.
³ Nicholas School of the Environment, Duke University, & National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
⁴ College of Public Health, George Mason University, Fairfax, VA, USA.
⁵ Division of Occupational & Environmental Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
⁶ Department of Epidemiology, Lazio Region Health Service, Rome, IT, & Imperial College, London, UK.
⁷ Epidemiology Unit, Istituto Superiore di Sanità, Rome, IT.
⁸ National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.

Philip J Landrigan et al. Ann Glob Health. 2025.

. 2025 Jun 6;91(1):28.

doi: 10.5334/aogh.4771. eCollection 2025.

¹ Global Observatory on Planetary Health, Boston College, Chestnut Hill, MA, USA and Centre Scientifique de Monaco, Monaco.
² Global Observatory on Planetary Health, Connell School of Nursing, Boston College, Chestnut Hill, MA, USA, and ISGlobal, Barcelona, Spain.
³ Nicholas School of the Environment, Duke University, & National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
⁴ College of Public Health, George Mason University, Fairfax, VA, USA.
⁵ Division of Occupational & Environmental Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
⁶ Department of Epidemiology, Lazio Region Health Service, Rome, IT, & Imperial College, London, UK.
⁷ Epidemiology Unit, Istituto Superiore di Sanità, Rome, IT.
⁸ National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.

No abstract available

Keywords: IARC Monographs; aspartame; cancer bioassays; evidence synthesis.

Conflict of interest statement

Authors Philip J. Landrigan and Kurt Straif serve on the Editorial Team for Annals of Global Health.

1. International Agency for Research on Cancer (IARC). Aspartame. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Vol 134. Lyon, France: IARC; 2024:1–533.
1. Soffritti M, Belpoggi F, Tibaldi E, Degli Esposti D, Lauriola M. Life‑span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ Health Perspect. 2007;115(9):1293–1297. doi: 10.1289/ehp.10271. - DOI - PMC - PubMed
1. Belpoggi F, Soffritti M, Padovani M, Degli Esposti D, Lauriola M, Minardi F. Results of long‑term carcinogenicity bioassay on Sprague‑Dawley rats exposed to aspartame administered in feed. Ann NY Acad Sci. 2006;1076:559–577. doi: 10.1196/annals.1371.080. - DOI - PubMed
1. Soffritti M, Belpoggi F, Manservigi M, et al. Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice. Am J Ind Med. 2010;53:1197–1206. doi: 10.1002/ajim.20896. - DOI - PubMed
1. Chiozzotto D, Soffritti M, Falcioni L, et al. Results of lifespan carcinogenicity bioassay on Sprague‑Dawley rats exposed to aspartame since foetal life. Eur J Oncol. 2011;16(2):81–97.