From signal to senescence: IFNγ drives muscle atrophy in myositis

Werner Stenzel¹, Hans-Hilmar Goebel¹, Marie-Therese Holzer^{1

2}

Affiliations

¹ Department of Neuropathology, Charité, Universitätsmedizin Berlin, 10117 Berlin, Germany.
² Division of Rheumatology and Systemic Inflammatory Diseases, III, Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

Editorial

Werner Stenzel et al. Brain. 2025.

. 2025 Aug 1;148(8):2601-2602.

doi: 10.1093/brain/awaf220.

Werner Stenzel¹, Hans-Hilmar Goebel¹, Marie-Therese Holzer^{1

2}

¹ Department of Neuropathology, Charité, Universitätsmedizin Berlin, 10117 Berlin, Germany.
² Division of Rheumatology and Systemic Inflammatory Diseases, III, Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

No abstract available

Comment on

Interferon-γ causes myogenic cell dysfunction and senescence in immune myopathies.
Hou C, Periou B, Gervais M, Martin L, Berthier J, Baba-Amer Y, Souvannanorath S, Lechapt-Zalcman E, Malfatti E, Gherardi RK, Relaix F, Bencze M, Authier FJ. Hou C, et al. Brain. 2025 Aug 1;148(8):2883-2898. doi: 10.1093/brain/awaf153. Brain. 2025. PMID: 40296760