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Meta-Analysis
. 2025 Aug 4;22(8):1383-1389.
doi: 10.1093/jsxmed/qdaf140.

Clinical efficacy and safety of selective dorsal neurectomy/cryoablation for treatment of premature ejaculation: systematic review and meta-analysis

Mehmet Gokhan Culha  1 , Mustafa Erkoc  1 , Caner Baran  1 , Levent Ozcan  1
Affiliations
Meta-Analysis

Clinical efficacy and safety of selective dorsal neurectomy/cryoablation for treatment of premature ejaculation: systematic review and meta-analysis

Mehmet Gokhan Culha et al. J Sex Med. .

Abstract

Introduction: Premature ejaculation (PE) is a prevalent sexual dysfunction with limited treatment options for some patients. Selective dorsal neurectomy/cryoablation (SDN/CA) has emerged as a potential treatment, aiming to desensitize the penis.

Objectives: To assess the efficacy of SDN/CA on intravaginal ejaculation latency time (IELT), PE-related questionnaires, treatment satisfaction, erectile function, and adverse events in the treatment of PE.

Method: A systematic review and meta-analysis were conducted, including randomized controlled trials, clinical trials, and prospective/retrospective studies. Databases such as Embase, PubMed, Cochrane, and Web of Science were searched. The Cochrane risk-of-bias tool and Risk of Bias in Non-randomized Studies of Interventions-I tool were used for quality assessment. IELT (sec), questionnaires (Premature Ejaculation Diagnostic Tool, Premature Ejaculation Profile, Sexual Satisfaction Score), erectile status (IIEF [International Index of Erectile Function]-5), and adverse events were evaluated. Comprehensive meta-analysis and R software were used for statistical analyses.

Results: Seven studies (235 patients) were included. SDN/CA significantly improved IELT (mean difference: 147.47 sec, P < .05). Questionnaires showed improvements in sexual satisfaction and ejaculation control. No meaningful change was observed in the erectile function. The adverse event rate was 11.17%, with no significant difference between groups.

Conclusion: SDN/CA is controversial as a treatment option for PE, affecting IELT and patient satisfaction. The heterogeneity of the included studies and short-term follow-up periods shed light on further research. However, further research into standard protocols and longer follow-ups is needed.

Keywords: IELT; dorsal nerve block; dorsal nerve cryoablation; premature ejaculation; selective dorsal neurectomy.

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