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. 2025 Mar 22;4(7):100663.
doi: 10.1016/j.gastha.2025.100663. eCollection 2025.

A Nationwide Retrospective Analysis of Socioeconomic Factors Associated With Eosinophilic Colitis: A Population-Based Study

Bibek Karki  1 , Samjhana Belbase  1 , Michelle Bernshteyn  2 , Ajit Brar  1 , Hussain Murtaza  3 , Nikky Maharjan  1 , Navindra Dhakal  4 , Subash Ghimire  2 , Pujan Kandel  5 , Calvin Ghimire  6 , Philip McDonald  1 , Matthew Lincoln  2 , Michael Georgetson  2
Affiliations

A Nationwide Retrospective Analysis of Socioeconomic Factors Associated With Eosinophilic Colitis: A Population-Based Study

Bibek Karki et al. Gastro Hep Adv. .

Abstract

Background and aims: Eosinophilic colitis (EC) is a rare gastrointestinal inflammation of the colon characterized by eosinophilic infiltration into the colonic wall. The study aimed to assess the socioeconomic factors associated with EC.

Methods: A retrospective cohort study was conducted using the 2016-2020 National Inpatient Sample, including adult patients (≥18 years) admitted with EC.

Results: Among 4353 EC cases identified, males are more likely to be hospitalized than females (51.8% vs 48.2%, P < .001). Caucasians consisted of 81.7% of total cases, followed by African Americans (8.1%), Hispanics (6.3%), and Asians (1.3%) (P < .001). 50.6% of EC cases had Private/Health Maintenance Organization insurance followed by Medicare (26.5%), Medicaid (15.7%), and 7.2% were uninsured (P < .001). Only 16.5% of patients had a Charlson Comorbidity Index ≥3.

Conclusion: Caucasians, males, and those with private insurance were more likely to be diagnosed with EC. The correlation between insurance coverage and hospitalizations shows health-care disparities and implies the need for equitable health-care delivery.

Keywords: Colitis; Disparities; Eosinophilic Gastrointestinal Disorders; Prognosis.

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Figures

Figure 1
Figure 1
Incidence of EC by year of diagnosis.
Figure 2
Figure 2
Prevalence of EC based on gender.
Figure 3
Figure 3
Prevalence of EC based on ethnicity.
Figure 4
Figure 4
Prevalence of EC based on median household income.
Figure 5
Figure 5
Prevalence of EC based on hospital location.
Figure 6
Figure 6
Prevalence of EC based on hospital types.
Supplementary Material
Supplementary Material
Overview of population characteristics of eosinophilic colitis.
See this image and copyright information in PMC

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