Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 May 27;12(6):ofaf316.
doi: 10.1093/ofid/ofaf316. eCollection 2025 Jun.

High-Dose Probiotic Mix of Lactobacillus Spp, Bifidobacterium Spp, Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea in Adults: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (SPAADA)

Affiliations
Comment

High-Dose Probiotic Mix of Lactobacillus Spp, Bifidobacterium Spp, Bacillus coagulans, and Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea in Adults: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (SPAADA)

Cynthia Isabel Ortiz-Lopez et al. Open Forum Infect Dis. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest. Both authors: No reported conflicts.

Comment in

Comment on

References

    1. Hodzhev V, Dzhambazov K, Sapundziev N, et al. High-dose probiotic mix of Lactobacillus spp, Bifidobacterium spp, Bacillus coagulans, and Saccharomyces boulardii to prevent antibiotic-associated diarrhea in adults: a multicenter, randomized, double-blind, placebo-controlled trial (SPAADA). Open Forum Infect Dis 2024; 11:ofae615. - PMC - PubMed
    1. Hofman DL, van Buul VJ, Brouns FJ. Nutrition, health, and regulatory aspects of digestible maltodextrins. Crit Rev Food Sci Nutr 2016; 56:2091–100. - PMC - PubMed
    1. Laudisi F, Di Fusco D, Dinallo V, et al. The food additive maltodextrin promotes endoplasmic reticulum stress-driven mucus depletion and exacerbates intestinal inflammation. Cell Mol Gastroenterol Hepatol 2019; 7:457–73. - PMC - PubMed
    1. Astina J, Sapwarobol S. Resistant maltodextrin and metabolic syndrome: a review. J Am Coll Nutr 2019; 38:380–5. - PubMed
    1. Hobbs CA, Saigo K, Koyanagi M, Hayashi SM. Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential. Toxicol Rep 2017; 4:554–9. - PMC - PubMed