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Case Reports
. 2025 Mar 8:59:130-133.
doi: 10.1016/j.jdcr.2025.02.012. eCollection 2025 May.

Merkel cell carcinoma in a patient with Birt-Hogg-Dubé syndrome

Danielle J Reed  1 , Yoshine Saito  1 , Jasmine C Meltzer  1 , Monica E Taylor  1 , Whitney A High  2 , Jia Yan  3 , Michael R Setzer  3 , Rajarshi Ghosh  3 , Magdalena A Walkiewicz  3   4 , Justin B Lack  5 , Lingling Miao  1 , Isaac Brownell  1
Affiliations
Case Reports

Merkel cell carcinoma in a patient with Birt-Hogg-Dubé syndrome

Danielle J Reed et al. JAAD Case Rep. .
No abstract available

Keywords: Birt-Hogg-Dubé syndrome; Merkel cell carcinoma; exome sequencing; folliculin; nonmelanoma skin cancer.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Clinical and histopathologic findings of fibrofolliculomas in our patient with Birt-Hogg-Dubé syndrome. A and B, Fibrofolliculomas on the neck and posterior auricular skin: 1-2 mm skin colored, dome shaped papules including some with central comedonal plugs. C, hematoxylin and eosin (H&E) staining of a fibrofolliculoma biopsied from supraclavicular skin showing epidermal strands extending from a central hair follicle with prominent perifollicular connective tissue. Original magnification 100×.
Fig 2
Fig 2
Clinical and histopathologic findings of Merkel cell carcinoma lesion. A, 1.4 cm nodule on the right proximal dorsal forearm. B, H&E section showing sheets and trabeculae of hyperchromatic basophilic cells. Immunohistochemistry stains were diffusely positive for (C) CK20 with a paranuclear dot staining pattern, and (D) chromogranin. Original magnification 100×. H&E, Hematoxylin and eosin.
See this image and copyright information in PMC

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References

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