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. 2025 May;14(2):200-218.
doi: 10.12997/jla.2025.14.2.200. Epub 2025 Apr 3.

Fatty Acids in Childhood Obesity: A Link Between Nutrition, Metabolic Alterations and Cardiovascular Risk

Belen Davico  1 , Maximiliano Martin  1 , Anabel Impa Condori  2 , Ezequiel Lozano Chiappe  1 , Laura Gaete  3 , Walter F Tetzlaff  1 , Amanda Yanez  1 , Viviana Osta  2 , María S Sáez  4 , Augusto Bava  4 , María F Godoy  2 , Patricia Palenque  3 , María G Ballerini  1 , Liliana Trifone  3 , Leonardo Gómez Rosso  1 , María S Feliu  2 , Fernando Brites  1
Affiliations

Fatty Acids in Childhood Obesity: A Link Between Nutrition, Metabolic Alterations and Cardiovascular Risk

Belen Davico et al. J Lipid Atheroscler. 2025 May.

Abstract

Objective: Childhood obesity, affected by dietary choices, increases cardiovascular risk. Obesity is associated with inflammation and altered glucose, iron and lipid metabolism. This study explores connections between dietary habits, plasma fatty acid profile, cardiovascular risk factors and childhood obesity.

Methods: We conducted a case-control study including 20 children and adolescents with obesity and 20 controls. Anthropometric parameters and food frequency questionnaires were registered. Glucose metabolism, iron parameters, lipid profile, fatty acids profile, and lipoprotein-associated phospholipase A2 (Lp-PLA2), cholesteryl ester transfer protein and paraoxonase 1 (PON 1) activities were evaluated. Correlation, regression and mediation analyses were performed.

Results: The group with obesity consumed more bakery products and less cereals, and presented higher myristic, palmitoleic, margaric and gamma-linolenic acids, along with lower linoleic, arachidic, gadoleic, eicosatrienoic and eicosapentaenoic (EPA) acids (p<0.05). They also exhibited altered glucose metabolism, a more atherogenic lipid profile, higher Lp-PLA2 and lower PON 1 activities (p<0.05). Consumption of several food groups correlated with metabolic alterations. Different correlations between pro-inflammatory, anti-inflammatory and obesity-related fatty acids, and cardiometabolic biomarkers were found, including: myristic acid with Lp-PLA2 (r=0.32, p<0.05), EPA acid with hs-CRP (r=-0.36, p<0.05) and gadoleic acid with PON1 (r=0.39, p<0.05). Mediation analyses revealed fatty acids and cardiometabolic markers as mediators of the association between dietary habits and obesity.

Conclusion: Children and adolescents with obesity presented disrupted glucose and lipid metabolism, vascular inflammation, attenuated antioxidant function and altered fatty acid composition. Direct and indirect associations between dietary habits, fatty acids, cardiometabolic markers and the presence of obesity were found.

Keywords: Fatty acids; High density lipoprotein; Lp-PLA2; Paraoxonase; Pediatric obesity.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1. Significant associations obtained in separate mediation analyses.
NEFA, non-esterified fatty acids; NS, not significant; EPA, eicosapentaenoic; HDL-C, high density lipoprotein cholesterol.
Fig. 2
Fig. 2. Direct and indirect interactions between dietary habits (triangles), fatty acids (rectangles), cardiometabolic markers (diamonds) and childhood obesity (circle).
HDL-C, high density lipoprotein cholesterol; EPA, eicosapentaenoic; NEFA, non-esterified fatty acids.
See this image and copyright information in PMC

References

    1. Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2016;17:95–107. - PubMed
    1. Horesh A, Tsur AM, Bardugo A, Twig G. Adolescent and childhood obesity and excess morbidity and mortality in young adulthood-a systematic review. Curr Obes Rep. 2021;10:301–310. - PubMed
    1. Jebeile H, Kelly AS, O’Malley G, Baur LA. Obesity in children and adolescents: epidemiology, causes, assessment, and management. Lancet Diabetes Endocrinol. 2022;10:351–365. - PMC - PubMed
    1. Verduci E, Bronsky J, Embleton N, Gerasimidis K, Indrio F, Köglmeier J, et al. Role of dietary factors, food habits, and lifestyle in childhood obesity development: a position paper from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2021;72:769–783. - PMC - PubMed
    1. Kavey RE. Combined dyslipidemia in childhood. J Clin Lipidol. 2015;9:S41–S56. - PubMed