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Review
. 2025 Sep 1;19(3):175-179.
doi: 10.1097/SPC.0000000000000763. Epub 2025 Jul 29.

Promising preclinical approaches to combating cancer-associated cachexia/tissue wasting

Savannah A Epstein  1   2   3 , Aneesha Dasgupta  1   2   3 , Jason D Doles  1   2   3
Affiliations
Review

Promising preclinical approaches to combating cancer-associated cachexia/tissue wasting

Savannah A Epstein et al. Curr Opin Support Palliat Care. .

Abstract

Purpose of review: To highlight promising pre-clinical work seeking to target cancer-associated tissue/muscle wasting.

Recent findings: This narrative review explores recent innovations and emerging/understudied aspects of cancer cachexia biology, highlighting representative studies across three key areas: (a) novel strategies for targeting established wasting pathways, (b) multimodal/combinatorial therapeutic approaches, and (c) mechanisms involving inter-tissue communication.

Summary: Though not exhaustive, this review highlights three key areas of pre-clinical research with the potential to inform and inspire future clinical trials aimed at mitigating cachexia and tissue wasting in cancer patients.

Keywords: cachexia; muscle wasting; preclinical targets.

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References

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