Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 10;20(6):e0324727.
doi: 10.1371/journal.pone.0324727. eCollection 2025.

A goat experimental epistaxis model: Hemostatic effect of stop nosebleeds device

Amani Abu-Shaheen  1 , Shroaq Saleh Aljanobui  2 , Falah Hassan Almohanna  3 , Mohsen Ayyash  4 , Sumayyia Marar  1 , Goran Matic  3 , Mohammed Hazazi  3 , Juneil Batalla  3 , Maaweya Awadalla  1 , Muaawia A Hamza  1
Affiliations

A goat experimental epistaxis model: Hemostatic effect of stop nosebleeds device

Amani Abu-Shaheen et al. PLoS One. .

Abstract

To stop epistaxis, a Saudi medical invention called "Stop Nosebleeds" with a patent was created. It is a silicone-based, adjustable device that is applied externally to the bridge of the nose and speeds up clotting by decreasing the temperature and the compressing effect of the device on the nose This study aims to examine the efficacy of the device in attaining hemostasis in goats with anterior nasal bleeding. An animal experimental nasal-bleeding model was conducted on ten goats in collaboration between King Fahad Medical City and King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. The left nostril was used as interventional wounds and the right nostril was used as control. Control wounds were treated with manual compression for 20 minutes. Interventional wounds were treated with the Stop Nosebleeds device. The second group of animals was heparinized and 2 wounds were created in each animal, one of which was being treated with the Stop Nosebleeds device, while the other was being treated with manual compression. The mean bleeding duration in the experimental group (both heparinized and non-heparinized goats) was 45.5 seconds (SD = 8.2), compared to 206.0 seconds (SD = 75.7) in the control group (U = 0.00, p < 0.001). The device stopped bleeding in 52.0 seconds and 39.0 seconds in the heparinized and non-heparinized experimental groups. While, the manual compression of epistaxis stopped bleeding in 252.5 seconds (SD = 84.7) and 159.2 seconds (SD = 15.7) in the heparinized and non-heparinized control groups, respectively. The device shows promise for clinical application, however, further research with larger sample sizes and human clinical trials are needed to validate its efficacy and safety. Additionally, the use of a goat model presents limitations in directly translating these results to human clinical practice, and these differences should be careful.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Stop Nosebleeds device used to stop epistaxis.
Fig 2
Fig 2. Stop the Nosebleeds device by applying pressure and cooling over the nasal bridge.
Fig 3
Fig 3. Roadmap of the study protocol and procedures.
Fig 4
Fig 4. Average bleeding time in both groups.
Fig 5
Fig 5. Mean bleeding duration between the non-heparinized and heparinized goats for both the experimental and control groups.
See this image and copyright information in PMC

References

    1. Ukawat L, Gupta A, Jain K. Demographic profile and etiology of epistaxis. Indian Journal of Otolaryngology and Head & Neck Surgery. 2024;76(4):3172–5. - PMC - PubMed
    1. Ayesha Tabassom JJD. Epistaxis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK435997/.
    1. Passali D, Damiani V, Passali FM, Tosca MA, Motta G, Ciprandi G. An International Survey on the pragmatic management of epistaxis. Acta Biomed. 2020;91(1-S):5–10. doi: 10.23750/abm.v91i1-S.9241 - DOI - PMC - PubMed
    1. Berry D, Carlson JN, Singletary E, Zideman DA, Ring J. Use of Cryotherapy for Managing Epistaxis in the First Aid Setting: A Scoping Review. Cureus. 2021;13(5):e14832. - PMC - PubMed
    1. Yeung WWY, Judd O. Reviving a Lost Art: Hot-water Irrigation Treatment for Intractable Epistaxis. An International Journal of Clinical Rhinology. 2020.

LinkOut - more resources