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Review
. 2025 Sep;165(3):106950.
doi: 10.1016/j.medcli.2025.106950. Epub 2025 Jun 9.

Small fiber neuropathy

[Article in English, Spanish]
Teresa Sevilla  1 , Lucía Galán Dávila  2
Affiliations
Review

Small fiber neuropathy

[Article in English, Spanish]
Teresa Sevilla et al. Med Clin (Barc). 2025 Sep.

Abstract

Small fiber neuropathy are a frequent cause of consultation in neurology. The estimated prevalence is of minimum 53 cases/100.000 inhabitants. The most frequent symptoms are neuropathic pain and dysautonomic disfunction. Symptoms, examination, neurophysologic test and skin biopsy are the pillars in its diagnosis. In the last years new causes of SFN has been described as for example mutations in sodium channel or immune causes as TS-HDS, FGFR-3 y plexina D1. Nowadays the treatment of SFN is mainly symptomatic including antidepressives and antiepileptics in a essay-mistake approach. However this new knowledge in the field may lead to a better definition of phenotype and genotype and a more personalized treatment.

Keywords: Biopsia de piel; Disautonomía; Dysautonomia; Neuropatía de fibra pequeña; Neuropatía dolorosa; Painful neuropathy; Skin biopsy; Small fiber neuropathy.

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