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. 2025 Jun 9.
doi: 10.1097/RLU.0000000000005980. Online ahead of print.

Targeted Radionuclide Therapy in Diffuse Intrinsic Brainstem Gliomas: Exploring Options Beyond the Finish Line

Yamini Dharmashaktu  1 , Madhavi Tripathi  1 , Sanjana Ballal  1 , K P Haresh  2 , Subhash Gupta  2 , Nishikant A Damle  1 , C S Bal  1
Affiliations

Targeted Radionuclide Therapy in Diffuse Intrinsic Brainstem Gliomas: Exploring Options Beyond the Finish Line

Yamini Dharmashaktu et al. Clin Nucl Med. .

Abstract

Of the pediatric brainstem gliomas, around 80% develop in the pons, with the vast majority of pontine tumors being diffuse intrinsic brainstem gliomas (DIPG), which tend to be high grade, locally infiltrative, and have a poor prognosis. We present a 12-year-old girl diagnosed with DIPG in July 2022, who received 60 Gy, 30 fractions of radical radiotherapy over 6 weeks, followed by temozolomide. With residual disease, the patient was referred to our department for the possibility of radiotheranostics. She underwent 68Ga PSMA PET/CT, which revealed tracer accumulation in the pontine mass and was subsequently given 2 cycles of Lu-177 PSMA 617 and 1 cycle of Ac-225 PSMA 617 therapy.

Keywords: DIPG; PRRT; pediatric tumors.

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Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

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