Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke

Jin Soo Lee¹, Ji Sung Lee², Seong Hwan Ahn³, Hyun Goo Kang⁴, Tae-Jin Song⁵, Dong-Ick Shin⁶, Hee-Joon Bae⁷, Chang Hun Kim⁸, Sung Hyuk Heo⁹, Jae-Kwan Cha¹⁰, Yeong Bae Lee¹¹, Eung Gyu Kim¹², Man Seok Park¹³, Hee-Kwon Park¹⁴, Jinkwon Kim¹⁵, Sungwook Yu¹⁶, Heejung Mo¹⁴, Sung Il Sohn¹⁷, Jee Hyun Kwon¹⁸, Jae Guk Kim¹⁹, Young Seo Kim²⁰, Jay Chol Choi²¹, Yang-Ha Hwang²², Keun Hwa Jung²³, Soo-Kyoung Kim⁸, Woo Keun Seo²⁴, Jung Hwa Seo¹⁰, Joonsang Yoo¹⁵, Jun Young Chang²⁵, Mooseok Park⁴, Kyu Sun Yum⁶, Chun San An²⁶, Byoung Joo Gwag²⁶, Dennis W Choi²⁷, Ji Man Hong¹, Sun U Kwon²⁵; SONIC and RODIN Investigators

Affiliations

¹ Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea.
² Clinical Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
³ Department of Neurology, Chosun University Hospital, Chosun University College of Medicine, Gwangju, Korea.
⁴ Department of Neurology, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.
⁵ Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
⁶ Department of Neurology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
⁷ Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
⁸ Department of Neurology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
⁹ Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.
¹⁰ Department of Neurology, Dong-A University Hospital, College of Medicine, Dong-A University, Busan, Korea.
¹¹ Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
¹² Department of Neurology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
¹³ Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Korea.
¹⁴ Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
¹⁵ Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
¹⁶ Department of Neurology, Korea University Anam Hospital, Korea University Medicine, Seoul, Korea.
¹⁷ Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.
¹⁸ Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
¹⁹ Department of Neurology, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea.
²⁰ Department of Neurology, Wonkwang University Hospital, School of Medicine, Wonkwang University, Iksan, Korea.
²¹ Department of Neurology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea.
²² Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
²³ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
²⁴ Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
²⁵ Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
²⁶ GNT Pharma Co., Ltd., Yongin, Korea.
²⁷ Department of Neurology, Stony Brook University School of Medicine, Stony Brook, NY, USA.

PMID: 40494590
PMCID: PMC12152461
DOI: 10.5853/jos.2024.05113

Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke

Jin Soo Lee et al. J Stroke. 2025 May.

. 2025 May;27(2):279-283.

doi: 10.5853/jos.2024.05113. Epub 2025 May 31.

Authors

Affiliations

¹ Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea.
² Clinical Research Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
³ Department of Neurology, Chosun University Hospital, Chosun University College of Medicine, Gwangju, Korea.
⁴ Department of Neurology, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.
⁵ Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
⁶ Department of Neurology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
⁷ Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
⁸ Department of Neurology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
⁹ Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.
¹⁰ Department of Neurology, Dong-A University Hospital, College of Medicine, Dong-A University, Busan, Korea.
¹¹ Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
¹² Department of Neurology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
¹³ Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Korea.
¹⁴ Department of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
¹⁵ Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
¹⁶ Department of Neurology, Korea University Anam Hospital, Korea University Medicine, Seoul, Korea.
¹⁷ Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.
¹⁸ Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
¹⁹ Department of Neurology, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Korea.
²⁰ Department of Neurology, Wonkwang University Hospital, School of Medicine, Wonkwang University, Iksan, Korea.
²¹ Department of Neurology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea.
²² Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
²³ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
²⁴ Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
²⁵ Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
²⁶ GNT Pharma Co., Ltd., Yongin, Korea.
²⁷ Department of Neurology, Stony Brook University School of Medicine, Stony Brook, NY, USA.

PMID: 40494590
PMCID: PMC12152461
DOI: 10.5853/jos.2024.05113

No abstract available

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Conflict of interest statement

Conflicts of interest

Dr. Jin Soo Lee reported receiving grants and personal fees from GNT Pharma outside the submitted work. Dr. Ji Sung Lee reported receiving personal fees from GNT Pharma during the conduct of the study. Dr. D. Choi reported receiving personal fees from GNT Pharma during the conduct of the study. Dr. Byoung Joo Gwag is the Chief Executive Officer and Dr. Chun San An is the Clinical Development Officer of GNT Pharma. No other disclosures were reported related to the submitted work.

Figures

**Figure 1.**
Distribution of the modified Rankin Scale (mRS) scores at 12 weeks in (A) unadjusted and (B) adjusted populations, respectively.

See this image and copyright information in PMC

References

1. Lee JS, Kang HG, Ahn SH, Song TJ, Shin DI, Bae HJ, et al. Nelonemdaz and patients with acute ischemic stroke and mechanical reperfusion: the RODIN randomized clinical trial. JAMA Netw Open. 2025;8:e2456535. - PMC - PubMed
1. Hong JM, Lee JS, Lee YB, Shin DH, Shin DI, Hwang YH, et al. Nelonemdaz for patients with acute ischemic stroke undergoing endovascular reperfusion therapy: a randomized phase II trial. Stroke. 2022;53:3250–3259. - PMC - PubMed
1. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 1999;22:391–397. - PubMed
1. Choi DW. Ionic dependence of glutamate neurotoxicity. J Neurosci. 1987;7:369–379. - PMC - PubMed
1. Gwag BJ, Lee YA, Ko SY, Lee MJ, Im DS, Yun BS, et al. Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine. J Cereb Blood Flow Metab. 2007;27:1142–1151. - PubMed

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Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke

Affiliations

Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke

Authors

Affiliations

Conflict of interest statement

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources