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Review
. 2025 Nov;176(3):304-311.
doi: 10.1111/imm.70000. Epub 2025 Jun 10.

Inflammation Perfect Storm: Cancer, Climate and Polarisation

Claudio Vieira da Silva  1
Affiliations
Review

Inflammation Perfect Storm: Cancer, Climate and Polarisation

Claudio Vieira da Silva. Immunology. 2025 Nov.

Abstract

Chronic systemic inflammation is increasingly recognised as a central pathological state driving the global burden of non-communicable diseases, most notably cancer, and significantly exacerbated by environmental stressors linked to climate change. This review elucidates the intricate and synergistic relationship between chronic inflammation and cancer, further amplified by the compounding effects of climate change and contemporary sociopolitical polarisation. We examine how biological, environmental and psychosocial factors converge to worsen chronic inflammation and increase cancer risk. Addressing this "perfect storm" of converging health threats necessitates a holistic and integrated approach that considers biological vulnerabilities, environmental degradation, the socioeconomic burden of health inequities, and the profound societal impacts of political polarisation to effectively mitigate this escalating global health crisis and promote health equity.

Keywords: cancer; chronic inflammation; climate change; environmental health; health equity; political polarisation.

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References

    1. D. Furman , J. Campisi , E. Verdin , et al., “Chronic Inflammation in the Etiology of Disease Across the Life Span,” Nature Medicine 25 (2019): 1822–1832, https://doi.org/10.1038/s41591‐019‐0675‐0.
    1. R. Medzhitov , “Inflammation 2010: New Adventures of an Old Flame,” Cell 140 (2010): 771–776, https://doi.org/10.1016/j.cell.2010.03.006.
    1. Q. Zhang , B. Zhu , and Y. Li , “Resolution of Cancer‐Promoting Inflammation: A New Approach for Anticancer Therapy,” Frontiers in Immunology 8 (2017): 71, https://doi.org/10.3389/fimmu.2017.00071.
    1. C. N. Serhan , “Pro‐Resolving Lipid Mediators Are Leads for Resolution Physiology,” Nature 510 (2014): 92–101, https://doi.org/10.1038/nature13479.
    1. P. Hunter , “The Inflammation Theory of Disease,” EMBO Reports 13 (2012): 968–970, https://doi.org/10.1038/embor.2012.142.

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