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Editorial
. 2025 May 19;15(5):102540.
doi: 10.5498/wjp.v15.i5.102540.

Bidirectional link between mood disorders and diabetic retinopathy

Affiliations
Editorial

Bidirectional link between mood disorders and diabetic retinopathy

Arshi Singh et al. World J Psychiatry. .

Abstract

The recently published article by Gao et al identifies risk factors for anxiety and depression in patients with diabetic retinopathy. We supplement that there is pathophysiological evidence to show a complex and possibly bidirectional relation between diabetes, diabetic retinopathy, and mood disorders, especially depression. Longitudinal studies may strengthen proof of a causal relationship between these diseases. A better understanding can help in the holistic management of these patients.

Keywords: Anxiety; Bidirectional; Correlation; Depression; Diabetes; Diabetic retinopathy; Mood disorders.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

References

    1. Gao S, Liu X. Analysis of anxiety and depression status and their influencing factors in patients with diabetic retinopathy. World J Psychiatry. 2024;14:1905–1917. - PMC - PubMed
    1. Ulhaq ZS, Soraya GV, Dewi NA, Wulandari LR. The prevalence of anxiety symptoms and disorders among ophthalmic disease patients. Ther Adv Ophthalmol. 2022;14:25158414221090100. - PMC - PubMed
    1. Chen X, Lu L. Depression in Diabetic Retinopathy: A Review and Recommendation for Psychiatric Management. Psychosomatics. 2016;57:465–471. - PubMed
    1. Duarte-Silva E, de Melo MG, Maes M, Filho AJMC, Macedo D, Peixoto CA. Shared metabolic and neuroimmune mechanisms underlying Type 2 Diabetes Mellitus and Major Depressive Disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110351. - PubMed
    1. Prabhakar V, Gupta D, Kanade P, Radhakrishnan M. Diabetes-associated depression: the serotonergic system as a novel multifunctional target. Indian J Pharmacol. 2015;47:4–10. - PMC - PubMed

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