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. 1977 Mar;11(3):392-5.
doi: 10.1128/AAC.11.3.392.

Effect of penicillin on streptomycin production by Streptomyces griseus

G Y Barabas, G Szabó

Effect of penicillin on streptomycin production by Streptomyces griseus

G Y Barabas et al. Antimicrob Agents Chemother. 1977 Mar.

Abstract

The correlation between the biosynthesis of the cell wall and the formation of streptomycin (SM) in Streptomyces griseus, influenced by a specific inhibitor of cell wall synthesis, was investigated. Penicillin, in subinhibitory concentrations (1 to 5 mug/ml), was added to cultures of S. griseus in different stages of its life cycle. The inhibitor decreased SM production, when young cultures were treated; however, there was an increase in SM formation when penicillin was added to older cultures. The explanation for these findings is discussed in detail.

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