Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Mar;11(3):528-33.
doi: 10.1128/AAC.11.3.528.

Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae

L P Elwell, M Roberts, L W Mayer, S Falkow

Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae

L P Elwell et al. Antimicrob Agents Chemother. 1977 Mar.

Abstract

Several beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae were examined for R plasmids. Penicillin-resistant strains isolated from men returning from the Far East and their contacts contained a 4.4 x 10(6)-dalton plasmid in common. Transformation studies and the isolation of a spontaneous penicillin-susceptible segregant showed that the structural gene for beta-lactamase was part of the 4.4 x 10(6)-dalton plasmid. An additional penicillin-resistant gonococcal strain isolated in London was found to harbor a 3.2 x 10(6)-dalton R plasmid. Deoxyribonucleic acid (DNA)-DNA duplex studies revealed that the penicillin-resistant gonococcal isolates contained a significant portion (about 40%) of the transposable DNA sequence, TnA, which includes the beta-lactamase gene commonly found on R plasmids of the Enterobacteriaceae and Haemophilus influenzae.

PubMed Disclaimer

References

    1. Nature. 1976 Oct 28;263(5580):731-8 - PubMed
    1. J Bacteriol. 1976 Oct;128(1):425-34 - PubMed
    1. Antimicrob Agents Chemother. 1972 Apr;1(4):283-8 - PubMed
    1. Infect Immun. 1974 Oct;10(4):712-7 - PubMed
    1. Lancet. 1976 Sep 25;2(7987):657-8 - PubMed

Publication types

LinkOut - more resources