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. 2025 Nov 29;42(4):324-326.
doi: 10.4274/tjh.galenos.2025.2025.0166. Epub 2025 Jun 11.

Engraftment Syndrome Following Autologous Stem Cell Transplantation in a Patient Receiving Nivolumab as Salvage Therapy

Esra Terzi Demirsoy  1 , Pınar Tarkun  1 , Ayfer Gedük  1 , Abdullah Hacıhanefioğlu  1 , Özgür Mehtap  1
Affiliations

Engraftment Syndrome Following Autologous Stem Cell Transplantation in a Patient Receiving Nivolumab as Salvage Therapy

Esra Terzi Demirsoy et al. Turk J Haematol. .
No abstract available

Keywords: Engraftment syndrome; Immune checkpoint inhibitors; Autologous stem celltransplantation.

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Conflict of interest statement

No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
On day 5 following the transplant, the patient developed a diffuse, completely blanchable, pink-to-red erythematous rash initially involving the face and arms, which subsequently spread to the trunk and lower extremities. The lesions coalesced into broad patches and plaques.
Figure 2
Figure 2
The onset of the patient’s rash and fever coincided with neutrophil engraftment. ASCT: Autologous hematopoietic stem cell transplantation.
See this image and copyright information in PMC

References

    1. Spitzer TR. Engraftment syndrome following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001;27(9):893–898. doi: 10.1038/sj.bmt.1703015. - DOI - PubMed
    1. Maiolino A, Biasoli I, Lima J, Portugal AC, Pulcheri W, Nucci M. Engraftment syndrome following autologous hematopoietic stem cell transplantation: definition of diagnostic criteria. Bone Marrow Transplant. 2003;31(5):393–397. doi: 10.1038/sj.bmt.1703855. - DOI - PubMed
    1. Cornell RF, Hari P, Drobyski WR. Engraftment syndrome after autologous stem cell transplantation: an update unifying the definition and management approach. Biol Blood Marrow Transplant. 2015;21(12):2061–2068. doi: 10.1016/j.bbmt.2015.08.030. - DOI - PMC - PubMed
    1. Mongkolrat S, Tantiworawit A, Niprapan P, Piriyakhuntorn P, Punnachet T, Hantrakun N, Rattanathammethee T, Hantrakool S, Chai-Adisaksopha C, Rattarittamrong E, Norasetthada L. Engraftment syndrome in autologous hematopoietic stem cell transplant patients: incidence, associated risk factors, features, and outcomes. Ann Transplant. 2024;29:e944043–1. doi: 10.12659/AOT.944043. - DOI - PMC - PubMed
    1. Taranto E, Hwang WT, Alfaro M, Surapaneni AS, Kaur Gill S, Feldman T, Randall MP, Spinner MA, Furqan F, Shah NN, Samara Y, Mei MG, Herrera AF, Moskowitz A, Shah GL, Svoboda J. Engraftment syndrome during autologous stem cell transplant in Hodgkin lymphoma patients treated with checkpoint inhibitors: a multi-center retrospective analysis. Blood. 2023;142(Suppl 1):3603. doi: 10.1182/blood-2023-187199. - DOI

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