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. 2025 Jun 11:1-5.
doi: 10.1080/14786419.2025.2512565. Online ahead of print.

Sesquiterpenoids from the Homalomena occulta (Lour.) Schott and their anti-osteoclast genesis activity

Bin Zhao  1 , Yi Wu  1 , Cheng Jiang  1 , Tao Tang  2 , Sicong Jiang  1 , Yuping Jiang  1
Affiliations

Sesquiterpenoids from the Homalomena occulta (Lour.) Schott and their anti-osteoclast genesis activity

Bin Zhao et al. Nat Prod Res. .

Abstract

Seventeen sesquiterpenoids were isolated from the aerial part of Homalomena occulta (Lour.) Schott. Two new compounds, Homoccusions A (1) and B (2), were determined by extensive spectroscopic methods, ECD calculations, as well as MS analysis. Then, the anti-osteoclast genesis effects of all compounds were studied and compounds 1-5 showed strong inhibition with an osteoclast genesis inhibitory ratio of over 90% at 10 μM.

Keywords: Homalomena occulta (Lour.) Schott; Homoccusions A and B; anti-osteoclast genesis effects; sesquiterpenoids.

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