Post-COPD: Can Emphysema Be Repaired?

J Michael Wells^{1

2

3}, Jerry A Krishnan^{4

5}, R Chad Wade^{1

2

3}, Greg Kinney⁶, Robert A Wise⁷, Enid Neptune⁷, Francesca Polverino⁸, Nicola A Hanania⁸, Matthew Moll^{9

10

11}, Melanie Königshoff¹², Divay Chandra¹², Frank Sciurba¹², Nathaniel Marchetti¹³, Raúl San José Estépar¹⁴, Alejandro A Diaz¹⁴, Karim El-Kersh¹⁵, Mario Castro¹⁶, Ying Zhang¹⁷, Janet T Holbrook¹⁸, Elizabeth A Sugar¹⁸, Monica Kraft¹⁹, Robert J Kaner^{20

21}, Barry Make²², Stephen Rennard²³

Affiliations

¹ Division of Pulmonary, Allergy, and Critical Care Medicine and.
² University of Alabama at Birmingham Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama.
³ Birmingham Veterans Affairs Healthcare System, Birmingham, Alabama.
⁴ Breathe Chicago Center, Division of Pulmonary, Critical Care, Sleep, and Allergy, and.
⁵ Institute for Healthcare Delivery and Design, University of Illinois Chicago, Chicago, Illinois.
⁶ Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
⁷ School of Medicine and.
⁸ Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, Texas.
⁹ Channing Division of Network Medicine.
¹⁰ Division of Pulmonary and Critical Care Medicine, and.
¹¹ Section on Pulmonary, Allergy, Critical Care, and Sleep Medicine, Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts.
¹² Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
¹³ Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
¹⁴ Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
¹⁵ Division of Pulmonary and Critical Care Medicine, University of Arizona College of Medicine, Phoenix, Arizona.
¹⁶ Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
¹⁷ Department of Biostatistics, College of Public Health, and.
¹⁸ Center for Clinical Trials and Evidence Synthesis, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
¹⁹ Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
²⁰ Division of Pulmonary and Critical Care Medicine and.
²¹ Department of Genetic Medicine, Weil Cornell Medicine, New York, New York; and.
²² Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado.
²³ Division of Pulmonary, Critical and Sleep Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.

PMID: 40498633
PMCID: PMC12756936 (available on 2026-09-01)
DOI: 10.1164/rccm.202408-1602PP

Post-COPD: Can Emphysema Be Repaired?

J Michael Wells et al. Am J Respir Crit Care Med. 2025 Sep.

. 2025 Sep;211(9):1600-1609.

doi: 10.1164/rccm.202408-1602PP.

Authors

Affiliations

¹ Division of Pulmonary, Allergy, and Critical Care Medicine and.
² University of Alabama at Birmingham Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama.
³ Birmingham Veterans Affairs Healthcare System, Birmingham, Alabama.
⁴ Breathe Chicago Center, Division of Pulmonary, Critical Care, Sleep, and Allergy, and.
⁵ Institute for Healthcare Delivery and Design, University of Illinois Chicago, Chicago, Illinois.
⁶ Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
⁷ School of Medicine and.
⁸ Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, Texas.
⁹ Channing Division of Network Medicine.
¹⁰ Division of Pulmonary and Critical Care Medicine, and.
¹¹ Section on Pulmonary, Allergy, Critical Care, and Sleep Medicine, Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts.
¹² Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
¹³ Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
¹⁴ Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
¹⁵ Division of Pulmonary and Critical Care Medicine, University of Arizona College of Medicine, Phoenix, Arizona.
¹⁶ Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.
¹⁷ Department of Biostatistics, College of Public Health, and.
¹⁸ Center for Clinical Trials and Evidence Synthesis, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
¹⁹ Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
²⁰ Division of Pulmonary and Critical Care Medicine and.
²¹ Department of Genetic Medicine, Weil Cornell Medicine, New York, New York; and.
²² Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado.
²³ Division of Pulmonary, Critical and Sleep Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.

PMID: 40498633
PMCID: PMC12756936 (available on 2026-09-01)
DOI: 10.1164/rccm.202408-1602PP

No abstract available

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References

1. Snider GL, Kleinerman J, Thurlbeck WM, Bengali ZH. The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. Am Rev Respir Dis 1985;132:182–185. - PubMed
1. Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, et al. Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature 2022;604:120–126. - PMC - PubMed
1. Butler JP, Loring SH, Patz S, Tsuda A, Yablonskiy DA, Mentzer SJ. Evidence for adult lung growth in humans. N Engl J Med 2012;367:244–247. - PMC - PubMed
1. Brody JS, Fisher AB, Gocmen A, DuBois AB. Acromegalic pneumonomegaly: lung growth in the adult. J Clin Invest 1970;49:1051–1060. - PMC - PubMed
1. Toppell KL, Atkinson R, Whitcomb ME. Lung growth in acromegaly. Am Rev Respir Dis 1973;108:1254–1258. - PubMed

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Post-COPD: Can Emphysema Be Repaired?

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Post-COPD: Can Emphysema Be Repaired?

Authors

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References

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