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Comment
. 2025 Jun 10;58(6):1364-1366.
doi: 10.1016/j.immuni.2025.05.010.

Mamma MIA! Decidual NK cells involved in fetal neurodevelopment

Norman Shreeve  1 , Francesco Colucci  2
Affiliations
Comment

Mamma MIA! Decidual NK cells involved in fetal neurodevelopment

Norman Shreeve et al. Immunity. .

Abstract

Maternal immune activation (MIA) can cause neurodevelopmental disorders, but the underlying mechanisms are incompletely understood. In this issue of Immunity, Bian et al. show that MIA triggers decidual NK cells to secrete granzyme B, which crosses the placenta and disturbs microglial homeostasis in the fetal brain, leading to abnormal neurodevelopment.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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