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Review
. 2025 Jul;109(4):787-801.
doi: 10.1016/j.mcna.2025.01.006. Epub 2025 Apr 12.

Diagnosis of Venous Thromboembolism

Affiliations
Review

Diagnosis of Venous Thromboembolism

Alicia Canas et al. Med Clin North Am. 2025 Jul.

Abstract

The diagnosis of acute venous thromboembolism (VTE) is challenging, as patients may have few of the classic signs or symptoms of deep vein thrombosis (DVT) or pulmonary embolism (PE). Incorporating clinical findings into validated diagnostic pathways greatly aids the diagnostic process. Clinical prediction tools, such as the Wells score and the Pulmonary Embolism Rule-out Criteria, should be used to guide diagnostic testing. When imaging is indicated, compression ultrasound and computed tomography pulmonary angiography are the tests of choice for DVT and PE, respectively.

Keywords: Compression ultrasound; Computed tomography pulmonary angiogram; Deep vein thrombosis; Diagnosis; Pulmonary embolism; Venous thromboembolism.

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Conflict of interest statement

Disclosure Dr A.S. Dunn received an honorarium in 2021 for a presentation sponsored by Janssen Pharmaceuticals, Belgium.

MeSH terms