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. 2025 Nov 1;110(11):2786-2791.
doi: 10.3324/haematol.2024.286964. Epub 2025 Jun 12.

First-in-human pharmacokinetic, safety, and preliminary efficacy studies of single- and multiple-dose FRSW117, a novel PEGylated recombinant factor VIII-Fc fusion protein with an extended half-life, in patients with severe hemophilia A

Feng Xue  1 , Shuxia Guo  2 , Ping Liu  2 , Weizhi Chen  3 , Yun Chen  4 , Qing Wen  4 , Haiying Hua  5 , Yu Cao  6 , Xianqi Feng  6 , Jing Sun  7 , Chongyuan Xu  7 , Renchi Yang  8
Affiliations

First-in-human pharmacokinetic, safety, and preliminary efficacy studies of single- and multiple-dose FRSW117, a novel PEGylated recombinant factor VIII-Fc fusion protein with an extended half-life, in patients with severe hemophilia A

Feng Xue et al. Haematologica. .
No abstract available

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References

    1. Song X, Zhong J, Xue F, et al. An overview of patients with haemophilia A in China: epidemiology, disease severity and treatment strategies. Haemophilia. 2021;27(1):e51-e59. - PubMed
    1. Stonebraker JS, Bolton-Maggs PHB, Brooker M, et al. The World Federation of Hemophilia Annual Global Survey 1999-2018. Haemophilia. 2020;26(4):591-600. - PubMed
    1. Srivastava A, Santagostino E, Dougall A, et al. WFH Guidelines for the Management of Hemophilia, 3rd edition. Haemophilia. 2020;26 Suppl 6:1-158. - PubMed
    1. Mannucci PM. Hemophilia treatment innovation: 50 years of progress and more to come. J Thromb Haemost. 2023;21(3):403-412. - PubMed
    1. von Drygalski A, Chowdary P, Kulkarni R, et al. Efanesoctocog alfa prophylaxis for patients with severe hemophilia A. N Engl J Med. 2023;388(4):310-318. - PubMed

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