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. 2025 Jun 12;135(15):e182472.
doi: 10.1172/JCI182472. eCollection 2025 Aug 1.

Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

Lara Haase  1   2 , Anouar Belkacemi  3   4 , Laura Neises  2 , Nicole Kiweler  2 , Christine Wesely  5 , Rosanna Huchzermeier  6 , Maja Bozic  7 , Arefeh Khakdan  7 , Marta Sánchez  7 , Arnaud Mary  1 , Nadja Sachs  4   8 , Hanna Winter  4   9 , Enrico Glaab  1 , Michael T Heneka  1 , Emiel Pc van der Vorst  6   10 , Michel Mittelbronn  7 , Johannes Meiser  2 , Jochen G Schneider  1   7
Affiliations

Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

Lara Haase et al. J Clin Invest. .
No abstract available

Keywords: Atherosclerosis; Cardiology; Macrophages; Vascular biology.

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Figures

Figure 1
Figure 1. Acod1 deletion has no effect on atherosclerosis but shows sex-dependent cholesterol metabolism in the Ldlr model.
Ldlr–/–Acod1–/– and control Ldlr–/– mice (6–12 weeks old) were fed a Western diet (Envigo, TD-88137) for 12 weeks. Plaque area was measured in the aortic root (A, n = 7–8/sex/group), thoracic/abdominal aorta (C, males n = 9–16, females n = 12–14), and aortic arch (D, n = 7–8/sex/group). Representative aortic arch images from females are shown (B and E). Circulating T cells were analyzed by flow cytometry (F, males n = 10–16, females n = 12–14, pooled right), gated as CD45+TCRβ+CD19– cells. Shown are representative dot plots (G). Weight gain (H, males n = 11–16, females n = 14–15), plasma cholesterol (I, n = 8–11/group), and liver IL-1β levels (J, n = 8–10/group, pooled right) were quantified. Data are shown as mean ± SD. *P < 0.05; ***P < 0.001 by Mann-Whitney U test (A, C, and D) or Welch’s t test (F–J). Scale bars: 300 μm (B) and 1 mm (E).
See this image and copyright information in PMC

Comment on

  • Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice doi: 10.1172/JCI173034

References

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