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. 2025 May 22;14(11):3631.
doi: 10.3390/jcm14113631.

The REVIVE Project: From Survival to Holistic Recovery-A Prospective Multicentric Evaluation of Cognitive, Emotional, and Quality-of-Life Outcomes in Out-of-Hospital Cardiac Arrest Survivors

Alice Mandrini  1   2 , Marco Mion  1   2   3 , Roberto Primi  1   2   4 , Sara Bendotti  1   2 , Alessia Currao  1   2   5 , Leila Ulmanova  1   2 , Carlo Arnò  6 , Filippo Dossi  6 , Cristian Fava  7 , Daniele Ghiraldin  8 , Davide Pegorin  8 , Paola Genoni  9 , Diego Maffeo  10 , Cinzia Dossena  11 , Silvia Affinito  12 , Giovanni Bertazzoli  13 , Francesco Cipullo  13 , Cecilia Fantoni  14 , Matteo Della Torre  15 , Silvia Frattini  15 , Gioele Papi  15 , Angelica Praderio  16 , Luca Tarantino  17 , Simone Savastano  1   2 , Enrico Baldi  1   2 , All The LombardiaCARe Researchers
Affiliations

The REVIVE Project: From Survival to Holistic Recovery-A Prospective Multicentric Evaluation of Cognitive, Emotional, and Quality-of-Life Outcomes in Out-of-Hospital Cardiac Arrest Survivors

Alice Mandrini et al. J Clin Med. .

Abstract

Background/Objectives: Most survivors of out-of-hospital cardiac arrest (OHCA) may suffer from cognitive, mental difficulties, and fatigue, which negatively impact their quality of life, despite a good physical recovery. However, no definitive data are available on this topic, so this study aims to assess the feasibility and acceptability of a centralized, sub-regional screening system for OHCA survivors in Italy and the prevalence of these disorders. Methods: OHCA survivors discharged with good neurological outcomes (Cerebral Performance Category (CPC) ≤ 2 and modified Ranking Scale (mRS) ≤ 3) from hospitals in the "Lombardia CARe" registry will be evaluated by a clinical psychologist using the Montreal Cognitive Assessment (MoCA), Hospital Anxiety and Depression Scale (HADS), EQ-5D-5L for quality of life, and the Impact of Event Scale-Revised (IES-R) at pre-discharge or within 15 days and then at 1, 3, 6, and 12 months. Patients with clinical issues will be referred for psychological support or to a community rehabilitation program. Feasibility will be defined as a recruitment rate ≥ 80% and acceptability as a retention rate ≥ 50% over 12 months. Results: Based on historical data from the Lombardia CARe, an estimated 350 eligible survivors are expected, which will allow estimation of a prevalence ranging between 20% and 30% with 5% precision and 95% confidence. Conclusions: This study will be the first in Italy to evaluate the feasibility and acceptability of a centralized, sub-regional system for pre-/post-discharge evaluation of cognitive impairment, mental health, and quality of life in a large cohort of OHCA survivors, documenting the prevalence of these disorders.

Keywords: cognitive dysfunction; emotional distress; health status assessment; out-of-hospital cardiac arrest; patient outcome assessment; quality of life; survivorship.

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Conflict of interest statement

E.B. and S.S. are part of the European Resuscitation Council Research-NET, of the ESCAPE-NET consortium, and of the PARQ-COST action. E.B. is part of the ILCOR Research and Registry Working Group. The remaining authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Location of the recruiting hospitals in the Lombardy region. Different colors identify the different provinces.
See this image and copyright information in PMC

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