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. 2025 May 27;26(11):5144.
doi: 10.3390/ijms26115144.

Gut Microbiota Dysbiosis in Endometriosis: A Potential Link to Inflammation and Disease Progression

Alexandra Irma Gabriela Baușic  1   2 , Francesca Scurtu  1   3 , Andrei Manu  1   4 , Daniela Roxana Matasariu  5   6 , Elvira Brătilă  1   2
Affiliations

Gut Microbiota Dysbiosis in Endometriosis: A Potential Link to Inflammation and Disease Progression

Alexandra Irma Gabriela Baușic et al. Int J Mol Sci. .

Abstract

Endometriosis is a complex gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus, leading to chronic inflammation, pain, and infertility. Recent research suggests that gut microbiota may play a crucial role in the pathogenesis and progression of endometriosis by modulating immune responses and oestrogen metabolism. This study investigates the intestinal microbiota composition in women with endometriosis and its potential as a disease diagnosis and severity biomarker. Stool samples from nine patients diagnosed with endometriosis were analysed using the GI Effects® Comprehensive Stool Profile test. The tests revealed significant dysbiosis, particularly an altered Firmicutes/Bacteroidetes ratio and increased levels of Bacteroidetes. Inflammatory markers, including β-glucuronidase and secretory IgA, were also elevated, suggesting a potential link between gut microbiota and systemic inflammation in endometriosis. While our findings align with previous studies, further research with larger cohorts is necessary to validate these observations. Understanding the role of the microbiome in endometriosis could open new avenues for noninvasive diagnostic tools in endometriosis and microbiota-targeted therapies.

Keywords: endometriosis; endometriosis biomarkers; intestinal microbiota; microbiome.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Frequency of test results for microorganisms in the intestinal microbiota of patients.
Figure 2
Figure 2
Results of the Firmicutes/Bacteroidetes clinical test in the patient group.
Figure 3
Figure 3
Results of the clinical tests for enzymes detected in the stool of patients in the group.
See this image and copyright information in PMC

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