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Comparative Study
. 1977 Jul;37(7 Pt 1):1982-5.

A primate model for study of methotrexate pharmacokinetics in the central nervous system

D G Poplack, W A Bleyer, J H Wood, M Kostolich, J L Savitch, A K Ommaya
  • PMID: 405092
Comparative Study

A primate model for study of methotrexate pharmacokinetics in the central nervous system

D G Poplack et al. Cancer Res. 1977 Jul.

Abstract

A new technique enabling repetitive sampling of cerebrospinal fluid (CSF) in unanesthetized rhesus monkeys was developed to study the pharmacokinetics of methotrexate (MTX) in the CSF. CSF and plasma MTX levels were monitored following intraventricular and intravenous MTX administration. CSF and plasma MTX disappearance curves in the monkey were virtually identical to curves generated in humans, suggesting that the mechanisms of transport between the CSF and plasma compartments are similar in both species. These observations validate this experimental primate model and indicate its potential application to the pharmacological study of CNS chemotherapeutic agents in man.

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