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Case Reports
. 2025 Jun;66(6):617-621.

Suspected clinical methemoglobinemia associated with administration of hydrogen peroxide 3% in a dog treated for acute ibuprofen ingestion

Dominique Dominguez  1 , Rebecca Walton  1
Affiliations
Case Reports

Suspected clinical methemoglobinemia associated with administration of hydrogen peroxide 3% in a dog treated for acute ibuprofen ingestion

Dominique Dominguez et al. Can Vet J. 2025 Jun.

Abstract
in English, French

An 8-month-old intact male golden retriever dog was presented to the emergency department of a large private-practice specialty hospital. The dog had become cyanotic and collapsed following administration (orogastric tube) of 1.4 mL/kg of hydrogen peroxide 3% to induce emesis for ibuprofen ingestion. The dog had severe methemoglobinemia (33%; reference range: 0.3 to 1.5%) and developed anemia. The methemoglobinemia resolved after 24 h of hospitalization with supportive care. Results from assessment with high-performance liquid chromatography/tandem mass spectrometry were consistent with ibuprofen ingestion, with no acetaminophen detected. Key clinical message: This case demonstrated methemoglobinemia in a dog following both ibuprofen ingestion and hydrogen peroxide 3% administration.

Suspicion de méthémoglobinémie clinique associée à l’administration de peroxyde d’hydrogène à 3 % chez un chien traité pour une ingestion aiguë d’ibuprofèneUn golden retriever mâle intact âgé de 8 mois a été présenté aux urgences d’un grand hôpital privé spécialisé. Le chien était devenu cyanosé et s’était effondré après l’administration (sonde orogastrique) de 1,4 mL/kg de peroxyde d’hydrogène à 3 % pour provoquer des vomissements liés à l’ingestion d’ibuprofène. Le chien présentait une méthémoglobinémie sévère (33 %; plage de référence : 0,3 à 1,5 %) et a développé une anémie. La méthémoglobinémie a disparu après 24 heures d’hospitalisation avec soins de support. Les résultats de l’évaluation par chromatographie en phase liquide à haute performance/spectrométrie de masse en tandem étaient compatibles avec une ingestion d’ibuprofène, sans acétaminophène détecté.Message clinique clé :Ce cas a démontré une méthémoglobinémie chez un chien après l’ingestion d’ibuprofène et l’administration de peroxyde d’hydrogène à 3 %.(Traduit par Dr Serge Messier).

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