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. 2025 May 29:15:1587257.
doi: 10.3389/fcimb.2025.1587257. eCollection 2025.

Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024

Guoqing Chen #  1 , Jin Cao #  2   3 , Yingli Qu  2 , Wenyan Tian  2 , Peng Shen  1 , Xuan Liu  2 , Qin Luo  2 , Qinqin Song  2 , Qi Wen  2 , Guangyu Xue  2 , Yuting Hu  2 , Qiangqiang Shi  2 , Lifeng Zhang  2 , Rundong Zhu  2 , Juan Song  2 , Jun Han  2
Affiliations

Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024

Guoqing Chen et al. Front Cell Infect Microbiol. .

Abstract

Objective: To understand the epidemiology and evolutionary characteristics of human adenovirus (HAdV) infecting children in Yancheng, China, during the winter of 2023-2024.

Methods: HAdV-positive throat swab samples were collected from pediatric patients in Yancheng. The Hexon, Penton base, and Fiber genes were amplified and sequenced for typing and phylogenetic analysis of HAdV.

Results: 170 HAdV-positive samples were collected and identified from children with acute respiratory infection (ARI) in Yancheng. A total of 133 samples were successfully amplified and sequenced for Hexon, Penton base, and Fiber genes. Phylogenetic analysis showed that HAdV-B3 was the dominant circulating strain, and two strains of B21, one strain of C1 and one strain of C5 were also identified.

Conclusion: During the winter of 2023-2024, HAdV infecting children in Yancheng was mainly the B3 type.

Keywords: adenovirus; epidemiological characteristics; genetic features; phylogenetic trees; respiratory infections.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Phylogenetic analysis of Hexon gene in Yancheng from 2023 to 2024. (The red font indicates the sample of this study, and the others are the prototype strains of each type.).
Figure 2
Figure 2
Phylogenetic analysis of Hexon (A), Penton base (B), and Fiber (C) genes of HAdV-B samples in Yancheng from 2023 to 2024 (The green circle represents the sequence of this study, the red triangle represents the prototype strain of each type, and the rest are reference sequences for each type).
Figure 3
Figure 3
Phylogenetic analysis of two HAdV-C samples in Yancheng from 2023 to 2024 based on Hexon (A), Penton base (B), and Fiber (C) genes (The yellow circle is the study sequence, the red triangle is the prototype strain of each type, and the rest is the reference sequence of each type).
Figure 4
Figure 4
Bootscanning analysis of the HAdV sequences using a sliding window of 200 nt moving in 20-nt steps. For each bootscanning analysis, the names of viruses of the query sequence were indicated in the plot.
See this image and copyright information in PMC

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