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. 2025 Mar;35(2):92-95.
doi: 10.4314/ejhs.v35i2.4.

Outcome of Renal Tissue Biopsy in Children and Adolescents Presenting with Features of Nephropathy at a Tertiary Hospital in Nigeria

Olanrewaju Timothy Adedoyin  1 , Olayinka Mikhail Buhari  2 , Olayinka Rasheed Ibrahim  3 , Olanrewaju Olubukola Oyedepo  4 , Olusola Abidemi M Adesiyun  5 , Abdurrazzaq Alege  6 , Harrifatta Difirwiti  1
Affiliations

Outcome of Renal Tissue Biopsy in Children and Adolescents Presenting with Features of Nephropathy at a Tertiary Hospital in Nigeria

Olanrewaju Timothy Adedoyin et al. Ethiop J Health Sci. 2025 Mar.

Abstract

Background: Oedematous renal lesions are significant chronic kidney diseases in childhood, with causes that may vary, especially in light of emerging illnesses like coronavirus, environmental pollution, and climate change. This study aimed to determine the histopathologic characteristics of oedematous renal lesions in children seen at a tertiary health facility in north-central Nigeria between January 2010 and December 2023.

Methods: This was a prospective study conducted on all children aged 2-18 years who presented with features of oedematous renal lesions between January 2010 and December 2023 at a health facility in north-central Nigeria. All eligible patients underwent renal biopsy.

Results: A total of 66 children with oedematous renal lesions were biopsied, comprising 35 males and 31 females, with a male-to-female ratio of 1.2:1. The age range of the subjects was 2-18 years, with a mean ± standard deviation (SD) of 7.8 ± 3.8 years. Of the 66 patients who consented to the biopsy, the histological findings were as follows: Minimal Change Nephropathy (MCNS)(n= 35, 53.0%), membranoproliferative glomerulonephritis (MPGN) (n=5, 7.6%), post-infectious glomerulonephritis (PSAGN) (n=3, 4.5%), and focal segmental glomerulosclerosis (FSGS)(n= 2, 3.0%).

Conclusion: This study shows that the predominant histopathologic characteristic of childhood oedematous renal lesions was MCNS in the cohort of children studied.

Keywords: Biopsy; Child; Nigeria; Oedema.

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Conflict of interest statement

Competing Interests: The authors declare that this manuscript was approved by all authors in its form and that no competing interest exists.

Figures

Figure 1
Figure 1
Histological characteristic of renal biopsy among the study children
See this image and copyright information in PMC

References

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