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Review
. 2025 Aug;77(4):889-906.
doi: 10.1007/s43440-025-00749-y. Epub 2025 Jun 13.

Inflammatory lung diseases: a clinical and scientific review of the latest advances and challenges

Ahmed A Katamesh  1 , Khaled Almansour  1 , Shimaa M Hassoun  2 , Ossama M Sayed  3 , Mohammed Khaled Bin Break  4   5 , Randa Mohammed Zaki  6   7 , Obaid Afzal  8 , Amr Radwan  9   10
Affiliations
Review

Inflammatory lung diseases: a clinical and scientific review of the latest advances and challenges

Ahmed A Katamesh et al. Pharmacol Rep. 2025 Aug.

Abstract
in English, German

Inflammatory lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, pulmonary sarcoidosis, and interstitial lung diseases (ILDs), represent a significant cause of morbidity and mortality globally. These conditions are characterized by chronic inflammation and tissue damage, leading to substantial respiratory compromise and impairing quality of life. This review aims to provide a comprehensive overview of pathogenesis, clinical features, and diagnostic approaches for inflammatory lung diseases, emphasizing their shared and distinct characteristics. The review synthesizes current literature on the genetic predisposition, environmental exposures, and immune responses involved in the development and progression of inflammatory lung diseases. It also examines the classification and staging of these conditions to highlight the importance of accurate diagnosis and effective management. Key findings include the complex interplay of numerous factors that contribute to disease development and progression, as well as an analysis of classification and staging systems that support clinical practice. By elucidating the underlying mechanisms and clinical features of inflammatory lung diseases, this review aims to inform the development of novel therapeutic strategies and enhance patient outcomes.

Not applicable.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: No human or animal studies have been performed in the work toward the completion of this article. Therefore, no ethical approvals are required. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

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