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. 2025 Aug;43(22):2461-2466.
doi: 10.1200/JCO-25-00183. Epub 2025 Jun 13.

Overall Survival After Allogeneic Transplantation in Advanced Cutaneous T-Cell Lymphomas (CUTALLO): A Propensity Score-Matched Controlled Prospective Study

Adèle de Masson  1   2   3 , Marie Beylot-Barry  4   5 , Caroline Ram-Wolff  1 , Jean-Baptiste Mear  6 , Stéphane Dalle  7 , Jacques Rouanet  8 , Saskia Ingen-Housz-Oro  9 , Corentin Orvain  10   11   12 , Julie Abraham  13 , Olivier Dereure  14   15 , Amandine Charbonnier  16 , Jérôme Cornillon  17 , Christine Longvert  18 , Stéphane Barete  19 , Serge Boulinguez  20 , Ewa Wierzbicka-Hainaut  21 , François Aubin  22 , Marie-Thérèse Rubio  23   24 , Marc Bernard  6 , Aline Schmidt-Tanguy  10 , Roch Houot  25 , Anne Pham-Ledard  4   5 , David Michonneau  2   3   26 , Hélène Labussière-Wallet  27 , Jean-David Bouaziz  1   2   3 , Florent Grange  28 , Hélène Moins-Teisserenc  3   29 , Katayoun Jondeau  30 , Samia Mourah  2   3   31 , Maxime Battistella  2   3   32 , Etienne Daguindau  33 , Michael Loschi  34 , Alexandra Picard  35 , Nathalie Franck  36 , Natacha Maillard  37 , Anne Huynh  38 , Stéphanie Nguyen  39 , Ambroise Marçais  40 , Guillaume Chaby  41 , Patrice Ceballos  42 , Yannick Le Corre  43 , Sébastien Maury  44 , Jacques-Olivier Bay  45 , Henri Adamski  46 , Emmanuel Bachy  47 , Edouard Forcade  48 , Gérard Socié  2   3   24 , Martine Bagot  1   2   3 , Sylvie Chevret  3   49   50 , Régis Peffault de Latour  3   24 ; CUTALLO Investigators, Groupe Français d’Etude des Lymphomes Cutanés and Société Française de Greffe de Moëlle et Thérapie Cellulaire
Collaborators, Affiliations

Overall Survival After Allogeneic Transplantation in Advanced Cutaneous T-Cell Lymphomas (CUTALLO): A Propensity Score-Matched Controlled Prospective Study

Adèle de Masson et al. J Clin Oncol. 2025 Aug.

Abstract

Cutaneous T-cell lymphomas (CTCLs) are rare, usually refractory, and sometimes fatal diseases. Patients presenting with advanced-stage CTCL usually exhibit poor long-term survival outcomes. Only very few treatments have improved progression-free survival (PFS) in advanced CTCL, and no treatment has increased overall survival (OS). In 2023, the results of the CUTALLO trial supported the hypothesis that hematopoietic stem-cell transplantation (HSCT) was associated with significantly longer PFS as compared with standard-of-care treatment among advanced-stage patients although HSCT did not significantly affect OS. We provide herein the final OS data pertaining to the same patient population after a longer median follow-up of 38.9 months. Of the 99 patients included in the analysis, 55 (56%) were assigned to the HSCT group, whereas 44 (44%) were allocated to the non-HSCT group. The updated survival analysis reported that 16 of 55 patients (29%) in the HSCT group and 22 of 44 patients (50%) in the non-HSCT group died. The median OS was not reached in the HSCT group and 51.5 months (95% CI, 26.9 to 51.5) in the non-HSCT group (hazard ratio, 0.40 [95% CI, 0.20 to 0.80]). Compared with the standard of care for advanced CTCL, after extended follow-up, allogeneic HSCT was associated with significantly longer OS.

Trial registration: ClinicalTrials.gov NCT02520908.

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