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. 2025 Jul;51(7):1393-1394.
doi: 10.1007/s00134-025-07992-0. Epub 2025 Jun 13.

Reconsidering high-MAP targets in septic shock: the need for cardiac function-oriented resuscitation. Authors' reply

Akira Endo  1   2 , Kazuma Yamakawa  3 , Takashi Tagami  4 , Yutaka Umemura  5 ; OPTPRESS investigators
Affiliations

Reconsidering high-MAP targets in septic shock: the need for cardiac function-oriented resuscitation. Authors' reply

Akira Endo et al. Intensive Care Med. 2025 Jul.
No abstract available

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Conflict of interest statement

Declarations. Conflicts of interest: The authors declare that they have no conflict of interest relevant to this article. Ethical approval: Not applicable.

References

    1. Huang G, Liu H, Xu P (2025) Reconsidering high-MAP targets in septic shock: the Need for cardiac function-oriented resuscitation. Intensive Care Med. https://doi.org/10.1007/s00134-025-07969-z
    1. Endo A, Yamakawa K, Tagami T et al (2025) Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. Intensive Care Med. https://doi.org/10.1007/s00134-025-07910-4 - DOI - PubMed - PMC
    1. De Backer D, Deutschman CS, Hellman J et al (2024) Surviving sepsis campaign research priorities 2023. Crit Care Med 52:268–296. https://doi.org/10.1097/CCM.0000000000006135 - DOI - PubMed
    1. Kazune S, Grabovskis A, Cescon C, Strike E, Vanags I (2019) Association between increased arterial stiffness and clinical outcomes in patients with early sepsis: a prospective observational cohort study. Intensive Care Med Exp 7:26. https://doi.org/10.1186/s40635-019-0252-3 - DOI - PubMed - PMC
    1. Sato R, Hasegawa D, Guo S, Nuqali AE, Moreno JEP (2025) Sepsis-induced cardiogenic shock: controversies and evidence gaps in diagnosis and management. J Intensive Care 13:1. https://doi.org/10.1186/s40560-024-00770-y - DOI - PubMed - PMC

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