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. 2025 Jun 13;23(1):65.
doi: 10.1186/s12969-025-01087-2.

Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review

Zahra Amirsardari  1   2   3 , Mohammadmahdi Abbasi  4 , Shana Ahadi  5 , Aida Rezaee  6 , Alireza Shalviri  7 , Farnaz Shavandi  8 , Reyhane Alidousti Shahraki  9 , Mohammad Mahdavi  3 , Mahshid Malakootian  10
Affiliations

Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review

Zahra Amirsardari et al. Pediatr Rheumatol Online J. .

Abstract

Objective: Previous research has identified the significant roles of non-coding RNAs (ncRNAs) in Kawasaki disease (KD). This systematic review aims to elucidate the involvement and significance of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in the pathogenesis and progression of KD.

Study design: A systematic search was conducted across four databases (PubMed, Embase, Scopus, and Web of Science) up to June 19, 2023, without year restrictions. The risk of bias was assessed using the Newcastle-Ottawa Scale.

Results: This review included 9 studies encompassing a total of 1894 individuals diagnosed with KD. Seven lncRNAs-Slco4a1, SOCS2-AS1, SRA, HCG22, MHRT, XLOC_006277, and HSD11B1-AS1-were found to be associated with KD, including polymorphisms such as lncRNA rs1814343 C > T and AC008392.1 rs7248320. Additionally, four circRNAs-circRNA-3302, circ7632, circANRIL, and hsa_circ_0123996-were associated with KD.

Conclusions: Both linear lncRNAs and circRNAs play critical roles in unraveling the mechanisms underlying KD, contributing to biomarker identification and potential therapeutic advances.

Keywords: Circular RNA; Kawasaki disease; Long non-coding RNA; Non-coding RNA; Systematic review.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All the authors agree with the publication of this systematic review. Competing interests: The authors declare no competing interests.

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