Surgery of T1/2 N0 M0 glottic cancer results in a better laryngeal preservation time compared to radiotherapy in a large German patient cohort

Manuel Christoph Ketterer¹, Thomas K Hoffmann², Simon Laban², Alexander Berghaus³, Martin Canis³, Christian Jacobi^{3

4}, Jens Peter Klussmann^{5

6}, Wendelin Foeringer^{5

6}, Roland Laszig⁷, Jens Pfeiffer⁷, Henning Bier⁴, Andreas Knopf^{8

9}

Affiliations

¹ Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5, 79106, Freiburg, Germany. manuel.christoph.ketterer@uniklinik-freiburg.de.
² Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
³ Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Grosshadern Campus Ludwig-Maximilian-University Munich, Marchioninistraße 15, 81377, Munich, Germany.
⁴ Otorhinolaryngology/Head and Neck Surgery, Klinikum Rechts Der Isar, Technical University Munich, Ismaninger Str. 22, 81675, München, Germany.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Klinikstrasse 33, 35392, Giessen, Germany.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany.
⁷ Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5, 79106, Freiburg, Germany.
⁸ Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5, 79106, Freiburg, Germany. andreas.knopf@uniklinik-freiburg.de.
⁹ Otorhinolaryngology/Head and Neck Surgery, Klinikum Rechts Der Isar, Technical University Munich, Ismaninger Str. 22, 81675, München, Germany. andreas.knopf@uniklinik-freiburg.de.

PMID: 40515846
DOI: 10.1007/s00405-025-09460-3

Surgery of T1/2 N0 M0 glottic cancer results in a better laryngeal preservation time compared to radiotherapy in a large German patient cohort

Manuel Christoph Ketterer et al. Eur Arch Otorhinolaryngol. 2025.

. 2025 Jun 14.

doi: 10.1007/s00405-025-09460-3. Online ahead of print.

Authors

Affiliations

¹ Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5, 79106, Freiburg, Germany. manuel.christoph.ketterer@uniklinik-freiburg.de.
² Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, Frauensteige 12, 89075, Ulm, Germany.
³ Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Grosshadern Campus Ludwig-Maximilian-University Munich, Marchioninistraße 15, 81377, Munich, Germany.
⁴ Otorhinolaryngology/Head and Neck Surgery, Klinikum Rechts Der Isar, Technical University Munich, Ismaninger Str. 22, 81675, München, Germany.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Klinikstrasse 33, 35392, Giessen, Germany.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany.
⁷ Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5, 79106, Freiburg, Germany.
⁸ Department of Otorhinolaryngology - Head and Neck Surgery, University Medical Centre Freiburg, Faculty of Medicine, University of Freiburg, Killianstraße 5, 79106, Freiburg, Germany. andreas.knopf@uniklinik-freiburg.de.
⁹ Otorhinolaryngology/Head and Neck Surgery, Klinikum Rechts Der Isar, Technical University Munich, Ismaninger Str. 22, 81675, München, Germany. andreas.knopf@uniklinik-freiburg.de.

PMID: 40515846
DOI: 10.1007/s00405-025-09460-3

Abstract

Objective: This retrospective study examined overall survival (OS), recurrence free survival (RFS), and laryngeal preservation time in a large cohort of 663 patients with T1/2 N0 M0 glottic cancer after transoral laser or open surgery vs radiotherapy.

Methods: A total of 595 surgically treated patients and 68 individuals after definitive radio(chemo)therapy (R (C)-T) were studied. Patient characteristics including sociological, surgical, and pathological data, OS and RFS as well as laryngeal preservation time were recorded and compared between various groups/cohorts.

Results: There were no significant differences in OS and RFS between surgically treated and conservatively treated patients. However, laryngeal preservation time was significantly higher in surgically treated patients (p < 0.001) (mean: 138.3 ± 2.2 months, versus 102.8 ± 7.6 months) than those under conservative treatment. The surgical treatment method (transoral vs. open partial resection) did not influence OS or RFS. Additionally, the rate of transoral vs. open surgery did not change over a decade. T2-stage patients showed significantly lower RFS than T1-stage patients. Initial R status significantly influenced OS and tumor recurrence.

Conclusion: The findings of this study exhibited a significantly longer laryngeal preservation time in patients with T1/2 N0 M0 glottic cancer treated surgically than in those treated with radiotherapy. No significant differences in OS or RFS were observed between open partial laryngectomy and transoral laser surgery. The R status had a significant impact on OS and RFS, with OS being significantly associated with an R0 status, regardless of T status or the surgical approach (open versus transoral). Laryngeal preservation surgery is recommended as a central therapeutic strategy for T1/2 N0 M0 glottic cancer because it has a higher laryngeal preservation rate than the conservative treatment. Given the high recurrence rate (18.5%) and the necessity of laryngo- (pharyng) ectomy in a substantial proportion of recurrent patients (7.7%), the choice of initial therapeutic approach is critical.

Keywords: Glottic laryngeal carcinoma; Head and neck cancer, radiotherapy; Open partial vertical laryngectomy; Overall survival; Surgical management; Transoral laser surgery.

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Conflict of interest statement

Declarations. Financial disclosures: None. Research involving human participants: Yes. Conflict of interest: The authors declare no conflict of interest.

References

1. Wiegand S (2016) Evidence-based review of laryngeal cancer surgery. Laryngorhinootologie 95(Suppl 1):S192-216 - PubMed
1. Krebs in Deutschland 2009/2010 9 (2013) Ausgabe. Robert Koch-Institut (Hrsg.) und die gesellschaft der epidemiologischen krebsregister in Deutschland e.V. (Hrsg.). Berlin
1. Chatenoud L, Garavello W, Pagan E, Bertuccio P, Gallus S, La Vecchia C, Negri E, Bosetti C (2015) Laryngeal cancer mortality trends in European countries. Int J Cancer. https://doi.org/10.1002/ijc.29833 - DOI - PubMed
1. Dirix P, Lambrecht M, Nuyts S (2010) Radiotherapy for laryngeal squamous cell carcinoma: current standards. Expert Rev Anticancer Ther 10:1461–1469 - DOI - PubMed
1. Chen JJ, Stessin A, Christos P, Wernicke AG, Nori D, Parashar B (2015) Differences in survival outcome between stage I and stage II glottic cancer: a SEER-based analysis. Laryngoscope 125:2093–2098 - DOI - PubMed

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Surgery of T1/2 N0 M0 glottic cancer results in a better laryngeal preservation time compared to radiotherapy in a large German patient cohort

Affiliations

Surgery of T1/2 N0 M0 glottic cancer results in a better laryngeal preservation time compared to radiotherapy in a large German patient cohort

Authors

Affiliations

Abstract

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources