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Review
. 2025 Jun 14:1-10.
doi: 10.1080/14992027.2025.2508728. Online ahead of print.

Approaches to managing ototoxicity in the workplace

Affiliations
Review

Approaches to managing ototoxicity in the workplace

Thais C Morata et al. Int J Audiol. .

Abstract

Objective: Ototoxic chemicals in the workplace can pose a risk to hearing and balance functions. Our objective was to identify evidence-based practices for occupational health settings in managing ototoxicity. This resulted in the document, Health Management of Workers Exposed to Ototoxic Chemicals, created by the International Ototoxicity Management Group.

Design: To develop a practical approach for any workplace, we reviewed a variety of sources and used an international panel of interdisciplinary experts. Evidence included data from experimental, observational, and review studies. Thirty-two subject matter experts were invited to review the document; twenty-two completed the review and unanimously endorsed the ototoxicity management system as proposed.

Results: Six key action steps were proposed to: (1) identify workers exposed to ototoxic chemicals, (2) perform auditory and vestibular assessments, (3) follow-up after monitoring health, (4) document worker data, (5) maintain healthy safety culture, and (6) review ototoxicity management approach. These steps focus on the management of workers who are at-risk for workplace ototoxic chemical exposure at any level (with or without concurrent noise exposures).

Conclusions: Early identification strategies include self-report questionnaires; auditory testing; vestibular screening; referrals for diagnosis; management of cases; and monitoring of exposure scenarios to prevent further cases.

Keywords: Ototoxic; hearing; occupational; ototoxicants; solvents; vestibular function; workplace exposures.

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Conflict of interest statement

Disclosure statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Examples of different levels for interventions focused on preventing ototoxicity in the workplace within a public health framework.
Figure 2.
Figure 2.
Summary of six key action steps in the management of ototoxicity in the workplace. Activities are each identified by a number (1–6) with the final step indicating that review of the entire process is also periodically needed.

References

    1. American Conference of Governmental Industrial Hygienists (ACGIH). 2024. TLV/BEI Guidelines. Overview. https://www.acgih.org/science/tlv-bei-guidelines/.
    1. Beaver C, and Schneider J. 2023. “Evaluating the Potential Impact of Ototoxicant Exposure on Worker Health.” Journal of Occupational and Environmental Hygiene 20 (11):520–535. 10.1080/15459624.2023.2240874. - DOI - PubMed
    1. Blair M, Slagley J, and Schaal NC. 2021. “Effect of Noise and Ototoxicants on Developing Standard Threshold Shifts at a U.S. Air Force Depot Level Maintenance Facility.” Journal of Occupational and Environmental Hygiene 18 (7):323–333. 10.1080/15459624.2021.1922693. - DOI - PubMed
    1. Blair M, Slagley J, and Schaal NC. 2022. “Pure Tone Audiometry Evaluation Method Effectiveness in Detecting Hearing Changes Due to Workplace Ototoxicant, Continuous Noise, and Impulse Noise Exposures.” Ear and Hearing 43 (4):1291–1299. 10.1097/AUD.0000000000001178. - DOI - PubMed
    1. Castellanos M-J, and Fuente A. 2016. “The Adverse Effects of Heavy Metals with and without Noise Exposure on the Human Peripheral and Central Auditory System: A Literature Review.” International Journal of Environmental Research and Public Health 13 (12):1223. 10.3390/ijerph13121223. - DOI - PMC - PubMed

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