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. 2025 Aug;75(4):100854.
doi: 10.1016/j.identj.2025.100854. Epub 2025 Jun 13.

Value Analysis of Preoperative Peripheral Blood Markers in the Identification of Benign From Malignant Parotid Gland Tumors

Zheng Ye  1 , Hui Dong  2 , Fuyong Sui  3
Affiliations

Value Analysis of Preoperative Peripheral Blood Markers in the Identification of Benign From Malignant Parotid Gland Tumors

Zheng Ye et al. Int Dent J. 2025 Aug.

Abstract

Objectives: To assess the value of preoperative peripheral blood inflammatory and nutritional parameters in distinguishing between benign and malignant parotid gland tumors.

Methods: A retrospective analysis was conducted on 79 patients with malignant parotid gland tumors and 79 patients with benign parotid gland tumors who were treated at the Second Hospital of Dalian Medical University from January 2015 to December 2024. Preoperative levels of total protein (TP), prealbumin (PA), albumin (Alb), albumin-to-globulin ratio (AGR), apolipoprotein A1-to-apolipoprotein B ratio (ApoA1/ApoB), and platelet-to-lymphocyte ratio (PLR) were compared between the malignant and benign tumor groups. The diagnostic value of these parameters in differentiating between benign and malignant parotid tumors was evaluated.

Results: The ApoA1/ApoB ratio and PLR were significantly higher in the malignant tumor group compared to the benign tumor group (P < .05). Conversely, TP, Alb, PA, and AGR were significantly lower in the malignant tumor group than in the benign tumor group (P < .05). Binary logistic regression analysis identified TP, PA, AGR, and ApoA1/ApoB as independent risk factors for parotid malignancy (P < .05). The optimal cut-off values for diagnosing parotid malignancy were 65.75 for TP, 248.46 for PA, 1.55 for AGR, and 1.45 for ApoA1/ApoB.

Conclusions: Preoperative peripheral blood inflammatory and nutritional markers may serve as valuable indicators for differentiating between benign and malignant parotid gland tumors, providing a potential adjunctive diagnostic tool. However, further large-scale studies are required to validate these findings.

Keywords: Albumin; Parotid tumors; Peripheral blood; Platelet-to-lymphocyte ratio; Total protein.

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Conflict of interest statement

Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig 1A
Fig 1A
OR the value of TP,PA,AGR.
Fig 1B
Fig 1B
The OR value of ApoA1/ApoB.
Fig 2
Fig 2
ROC curves of peripheral blood indicators for diagnosing malignant parotid gland tumors.
See this image and copyright information in PMC

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References

    1. Lewis A.G., Tong T., Maghami E. Diagnosis and management of malignant salivary gland tumors of the parotid gland. Otolaryngol Clin North Am. 2016;49(2):343–380. - PubMed
    1. Andrianopoulou S., Fiedler L.S., Lippert B.M., et al. A retrospective 8-year single institutional study in Germany regarding diagnosis, treatment, and outcome of malignant parotid tumors. Int J Surg Oncol. 2024;2024 - PMC - PubMed
    1. Gautam S.K., Kumar S., Singh H.P., et al. Clinico-pathological profile of parotid gland tumors at a tertiary care center in North India. Nat J Maxillofac Surg. 2023;14(3):438–443. - PMC - PubMed
    1. Choi S.Y., Lee E., Kim E., et al. Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors. BMC Cancer. 2021;21(1):178. - PMC - PubMed
    1. Ettl T., Schwarz-Furlan S., Gosau M., et al. Salivary gland carcinomas. Oral Maxillofac Surg. 2012;16(3):267–283. - PubMed