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Clinical Trial
. 2025 Jun 13;6(6):100600.
doi: 10.1016/j.medj.2025.100600.

More than just another IDH inhibitor: Insights from the HMPL-306 phase 1 trial

Ted M Getz  1 , Jan Philipp Bewersdorf  2
Affiliations
Clinical Trial

More than just another IDH inhibitor: Insights from the HMPL-306 phase 1 trial

Ted M Getz et al. Med. .

Abstract

Resistance to isocitrate dehydrogenase (IDH) inhibitors poses a significant challenge in acute myeloid leukemia (AML), indicating a need for novel IDH inhibitors. Hu et al. report the results of a phase 1 study of the dual IDH1/2 inhibitor HMPL-306 in relapsed/refractory IDH-mutant AML.1 The study highlights its manageable safety profile and robust preliminary efficacy, suggesting that it may be a valuable AML therapy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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