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Review
. 2025 Jun 16.
doi: 10.1007/s11357-025-01718-2. Online ahead of print.

HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging

Sophie Guyonnet  1   2 , Claudie Hooper  3 , Heike A Bischoff-Ferrari  1   4 , Angelo Parini  5 , Yohan Santin  5 , Jean-Philippe Pradère  6 , Cédric Dray  6 , Bruno Vellas  1   2 ; I. H. U. HealthAge INSPIRE/Open Science study group
Collaborators, Affiliations
Review

HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging

Sophie Guyonnet et al. Geroscience. .

Abstract

HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the "INStitute for Prevention" "healthy aging" and "medicine Rejuvenative" (INSPIRE) human translational, outbred SWISS mice and African turquoise killifish (GRZ strain) cohorts in which aging is studied based on the concept of intrinsic capacity (IC). In this narrative review, we describe the three INSPIRE aging models (human cohort, n = 1109, age range 20 -102 years old with mean age ± standard deviation, 62.4 ± 19.0 years and 61.9% female; outbred SWISS mice, n = 1576 and African Turquoise killifish, n = 300) and explain how IC is assessed at the clinical (in humans) and biological level over time. HealthAge strives to elucidate the underlying biology of IC and to identify biomarkers of IC declines and novel gero-therapeutics using the clinical and biological data and biospecimens collected prospectively in the three species. The data sharing policy will foster scientific discovery through new multi-disciplinary collaborations. Thus, HealthAge will promote healthy aging using a unique translational platform based on IC phenotyping with the ultimate goal of preventing loss of human independence and alleviating health costs associated with an aging population.

Keywords: Aging; Biomarkers; HealthAge; ICOPE; INSPIRE; Intrinsic capacity.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The INSPIRE-T human study was approved by the French Ethics Committee located in Rennes (CPP Ouest V), and the study was registered at http://clinicaltrials.gov (NCT04224038). All participants signed informed consent to participate. All animal procedures were performed in accordance with International Guidelines on Animal Experimentation and with the French Ministry of Agriculture license. The mouse experimentation protocol was approved by the Toulouse University local ethics committee and by the Ministry of Superior Education and Research under the agreements APAFIS2019120614331282 and APAFIS2020022409196014. This investigation complied with the Guide for Care and Use of Laboratory Animals published by Directive 2010/63/EU of the European Parliament. Competing interests: The authors declare no competing interests.

References

    1. “IHU HealthAge – soyez acteurs du bien vieillir,” INSPIRE. Accessed: Jan. 14, 2025. [Online]. Available: https://inspire.chu-toulouse.fr/fr/
    1. Garmany A, Yamada S, Terzic A. Longevity leap: mind the healthspan gap. NPJ Regen Med. 2021;6:57. https://doi.org/10.1038/s41536-021-00169-5 . - DOI - PubMed - PMC
    1. “The World report on ageing and health,” http://apps.who.int/iris/bitstream/10665/186463/1/9789240694811_eng.pdf?... .
    1. Beard JR, et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet. 2016;387(10033):2145–54. https://doi.org/10.1016/S0140-6736(15)00516-4 . - DOI - PubMed
    1. Cesari M, et al. Evidence for the domains supporting the construct of intrinsic capacity. J Gerontol A Biol Sci Med Sci. 2018;73(12):1653–60. https://doi.org/10.1093/gerona/gly011 . - DOI - PubMed

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