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. 2025 Jun 16.
doi: 10.1007/s10461-025-04788-7. Online ahead of print.

Health-Related Quality of Life Among People Living with HIV in Vietnam, a Three-Year Longitudinal Analysis

Hao T Duong  1   2 , Cuong D Do  3 , Donn J Colby  4 , Todd M Pollack  5   6
Affiliations

Health-Related Quality of Life Among People Living with HIV in Vietnam, a Three-Year Longitudinal Analysis

Hao T Duong et al. AIDS Behav. .

Abstract
in English, Spanish

This study examined changes in health-related quality of life (HRQOL) among people living with HIV in Vietnam over three years following antiretroviral therapy (ART) initiation. We analyzed data from a randomized trial of 639 ART-naïve patients in which HRQOL was measured using the SF-8 instrument. Mixed effects logistic regression was used to assess changes in HRQOL over time and identify associated factors. At baseline, 57.5% reported low HRQOL. HRQOL improved rapidly after ART initiation, with 89.0% reporting good HRQOL at 3 months and 96.4% at 36 months. Compared with men, women had slower improvement in HRQOL over time. Factors positively associated with HRQOL included higher BMI and alcohol use, while food insecurity, history of tuberculosis, advanced clinical stages, and TDF-based regimens were negatively associated. Older age was linked to poorer HRQOL outcomes. These findings highlight the effectiveness of ART in improving HRQOL while also revealing disparities in HRQOL improvements.

Este estudio examinó los cambios en la calidad de vida relacionada con la salud (CVRS) en personas que viven con VIH en Vietnam durante tres años tras iniciar la terapia antirretroviral (TAR). Se analizaron datos de un ensayo aleatorizado con 639 pacientes naïve a TAR, midiendo la CVRS con el instrumento SF-8. Se utilizó regresión logística de efectos mixtos para evaluar los cambios y factores asociados. Al inicio, el 57,5% reportó baja CVRS. La CVRS mejoró rápidamente tras la TAR, con un 89,0% reportando buena CVRS a los 3 meses y un 96,4% a los 36 meses. En comparación con los hombres, las mujeres mostraron mejoras más lentas. Un mayor IMC y el consumo de alcohol se asociaron positivamente, mientras que la inseguridad alimentaria, antecedentes de tuberculosis, estadios clínicos avanzados y regímenes basados en TDF se asociaron negativamente. La edad avanzada se vinculó a peores resultados. Estos hallazgos destacan la efectividad de la TAR y las disparidades en las mejoras de la CVRS.

Keywords: ART; HIV; HRQOL; Longitudinal study; PLHIV; Quality of life; SF-8; Vietnam.

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Conflict of interest statement

Declarations. Competing Interests: TMP receives funding from Gilead Sciences through a grant to Beth Israel Deaconess Medical Center (Boston, MA, USA) and has received travel support from Gilead Sciences. HTD, CDD, and DJC report no competing interests.

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References

    1. UNAIDS, UNAIDS Global AIDS update. The path that ends AIDS: UNAIDS Global AIDS Update 2023. Geneva: Joint United Nations Programme on HIV/AIDS; 2023. Licence: CC BY-NC-SA 3.0 IGO. Jt United Nations Program HIV/AIDS 2023;6.
    1. Marcus JL, Chao CR, Leyden WA, Xu L, Quesenberry CP, Klein DB, et al. Narrowing the gap in life expectancy between HIV-infected and HIV-uninfected individuals with access to care. J Acquir Immune Defic Syndr. 2016. https://doi.org/10.1097/QAI.0000000000001014 . - DOI - PubMed - PMC
    1. Lazarus JV, Safreed-Harmon K, Barton SE, Costagliola D, Dedes N, del Amo Valero J, et al. Beyond viral suppression of HIV - the new quality of life frontier. BMC Med. 2016. https://doi.org/10.1186/s12916-016-0640-4 . - DOI - PubMed - PMC
    1. Miners A, Phillips A, Kreif N, Rodger A, Speakman A, Fisher M, et al. Health-related quality-of-life of people with HIV in the era of combination antiretroviral treatment: a cross-sectional comparison with the general population. Lancet HIV. 2014. https://doi.org/10.1016/S2352-3018(14)70018-9 . - DOI - PubMed - PMC
    1. Safreed-Harmon K, Anderson J, Azzopardi-Muscat N, Behrens GMN, d’Arminio Monforte A, Davidovich U, et al. Reorienting health systems to care for people with HIV beyond viral suppression. Lancet HIV. 2019. https://doi.org/10.1016/S2352-3018(19)30334-0 . - DOI - PubMed

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